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Procedure

Control for Atrial Fibrillation (TANTRA Trial)

N/A
Waitlist Available
Led By Andrea Natale, MD
Research Sponsored by Texas Cardiac Arrhythmia Research Foundation
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 3 years
Awards & highlights

TANTRA Trial Summary

This study aims to examine the long-term success rate of catheter ablation in non-paroxysmal atrial fibrillation patients using different ablation strategies such as : (i) pulmonary vein antrum isolation (PVAI) + isolation of left atrial posterior wall, (ii) PVAI plus scar homogenization, (iii) PVAI plus isolation of posterior wall plus ablation of non-PV triggers [ PVAI: Pulmonary Vein Antrum Isolation Non-PV triggers: Triggers arising from sites other than pulmonary veins]

Eligible Conditions
  • Atrial Fibrillation

TANTRA Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~3 years
This trial's timeline: 3 weeks for screening, Varies for treatment, and 3 years for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Recurrence of atrial arrhythmia
Secondary outcome measures
Improvement in quality of life

TANTRA Trial Design

3Treatment groups
Active Control
Group I: ControlActive Control1 Intervention
Pulmonary Vein Antrum Isolation (PVAI) + isolation of left atrial posterior wall
Group II: Study IIActive Control3 Interventions
PVAI + isolation of left atrial posterior wall + non-PV triggers ablation
Group III: Study IActive Control2 Interventions
PVAI+ scar homogenization

Find a Location

Who is running the clinical trial?

Texas Cardiac Arrhythmia Research FoundationLead Sponsor
37 Previous Clinical Trials
13,194 Total Patients Enrolled
26 Trials studying Atrial Fibrillation
6,459 Patients Enrolled for Atrial Fibrillation
RCCS Monzino Hospital, Milan, ItalyUNKNOWN
1 Previous Clinical Trials
120 Total Patients Enrolled
Ospedale dell'Angelo, Venezia-MestreOTHER
6 Previous Clinical Trials
2,994 Total Patients Enrolled
1 Trials studying Atrial Fibrillation
86 Patients Enrolled for Atrial Fibrillation

Frequently Asked Questions

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Recent research and studies
clinicaltrials.govStudy
Pulmonary Vein Antrum Isolation (PVAI) Plus Scar Homogenization and Non-PV Triggers Ensure Long-term Recurrence-free Survival in Non-paroxysmal Atrial Fibrillation
Andrea Natale 2013. "Pulmonary Vein Antrum Isolation (PVAI) Plus Scar Homogenization and Non-PV Triggers Ensure Long-term Recurrence-free Survival in Non-paroxysmal Atrial Fibrillation". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT01672138.
All > Scar
~15 spots leftby Apr 2025
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