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Device

EBV for Emphysema (LIBERATE Trial)

N/A
Waitlist Available
Led By Gerard Criner, MD
Research Sponsored by Pulmonx Corporation
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 1 year
Awards & highlights

LIBERATE Trial Summary

This trial is testing a new device to help patients with severe emphysema by reducing the size of their lungs.

Eligible Conditions
  • Emphysema

LIBERATE Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~1 year
This trial's timeline: 3 weeks for screening, Varies for treatment, and 1 year for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Forced Expiratory Volume in 1-second (FEV1)
Secondary outcome measures
6-minute Walk Distance
FEV1 Post-bronchodilator Absolute Change
St. George's Respiratory Questionnaire (SGRQ)

LIBERATE Trial Design

2Treatment groups
Experimental Treatment
Group I: Optimal Medical ManagementExperimental Treatment1 Intervention
This study arm will receive maximal medical management, including smoking cessation program support if necessary, pulmonary rehabilitation, usual medications and oxygen supplementation as necessary.
Group II: EBV and Optimal Medical ManagementExperimental Treatment1 Intervention
This study arm will undergo EBV treatment along with optimal medical management, including smoking cessation program, pulmonary rehabilitation, usual medications and oxygen supplementation as necessary.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
EBV
2013
N/A
~190

Find a Location

Who is running the clinical trial?

Pulmonx CorporationLead Sponsor
14 Previous Clinical Trials
1,042 Total Patients Enrolled
13 Trials studying Emphysema
1,024 Patients Enrolled for Emphysema
Gerard Criner, MDPrincipal InvestigatorTemple University Hospital, Philadelphia, PA
9 Previous Clinical Trials
5,624 Total Patients Enrolled
5 Trials studying Emphysema
3,066 Patients Enrolled for Emphysema

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Does this experiment accommodate elderly participants?

"This trial is limited to patients aged 40-75. For those under 18 and over 65, there are 1 and 29 trials respectively that may fit their criteria."

Answered by AI

Are there any locations in the US that are administering this research?

"El Camino Hospital in Mountain View, Arizona, Arizona Pulmonary Specialists in Phoenix, South carolina and Medical University of South Carolina in Charleston are all inviting patients to enroll. Additionally, 17 other sites across the United States have been selected for this trial."

Answered by AI

Is the current recruitment period of this clinical trial still open?

"As per the information provided on clinicaltrials.gov, participant recruitment for this medical trial has ceased at present. This study was first posted in July 2013 and last updated in September 2022. Despite no longer recruiting patients, there are still 30 other active trials searching for volunteers currently available."

Answered by AI

Do I satisfy the criteria to join this experimental endeavor?

"Eligibility for this research is limited to individuals with emphysema between the ages of 40 and 75. As such, roughly 190 patients are required."

Answered by AI

Who else is applying?

What state do they live in?
California
What portion of applicants met pre-screening criteria?
Met criteria
Recent research and studies
Annals of the American Thoracic SocietyJournal
Effect of Zephyr Endobronchial Valves on Dyspnea, Activity Levels, and Quality of Life at One Year. Results from a Randomized Clinical Trial
Dransfield, Mark T., Justin L. Garner, Surya P. Bhatt, Dirk-Jan Slebos, Karin Klooster, Frank C. Sciurba, Pallav L. Shah, et al.. 2020. “Effect of Zephyr Endobronchial Valves on Dyspnea, Activity Levels, and Quality of Life at One Year. Results from a Randomized Clinical Trial”. Annals of the American Thoracic Society. American Thoracic Society. doi:10.1513/annalsats.201909-666oc.
American Journal of Respiratory and Critical Care MedicineJournal
A Multicenter Randomized Controlled Trial of Zephyr Endobronchial Valve Treatment in Heterogeneous Emphysema (LIBERATE)
Criner, Gerard J., Richard Sue, Shawn Wright, Mark Dransfield, Hiram Rivas-Perez, Tanya Wiese, Frank C. Sciurba, et al.. 2018. “A Multicenter Randomized Controlled Trial of Zephyr Endobronchial Valve Treatment in Heterogeneous Emphysema (LIBERATE)”. American Journal of Respiratory and Critical Care Medicine. American Thoracic Society. doi:10.1164/rccm.201803-0590oc.
American Journal of Respiratory and Critical Care MedicineJournal
A Multicenter Randomized Controlled Trial of Zephyr Endobronchial Valve Treatment in Heterogeneous Emphysema (LIBERATE)
Criner, Gerard J., Richard Sue, Shawn Wright, Mark Dransfield, Hiram Rivas-Perez, Tanya Wiese, Frank C. Sciurba, et al.. 2018. “A Multicenter Randomized Controlled Trial of Zephyr Endobronchial Valve Treatment in Heterogeneous Emphysema (LIBERATE)”. American Journal of Respiratory and Critical Care Medicine. American Thoracic Society. doi:10.1164/rccm.201803-0590oc.
clinicaltrials.govStudy
Pulmonx Endobronchial Valves Used in Treatment of Emphysema (LIBERATE Study)
2013. "Pulmonx Endobronchial Valves Used in Treatment of Emphysema (LIBERATE Study)". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT01796392.
~16 spots leftby Apr 2025
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