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Hyperpolarized 129Xe MRI for Lung Disease

N/A

Recruiting

Led By Parameswaran Nair, MD, PhD

Research Sponsored by McMaster University

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

No current or previous history of respiratory infection or disease

Subjects male or female aged 18-85 years

Timeline

Screening 3 weeks

Treatment Varies

Follow Up 1-5 years

Awards & highlights

Study Summary

This trial will use magnetic resonance imaging to study the lungs of people with and without lung disease, in order to better understand how the lungs work and how to treat them better.

Who is the study for?

This trial is for healthy adults and those with various lung diseases, aged 18-85. Participants must understand English and consent to the study. Exclusions include pregnancy, inability to perform certain lung tests, severe claustrophobia, or having metal implants that affect MRI safety.Check my eligibility

What is being tested?

The study explores the use of hyperpolarized xenon-129 (129Xe) MRI in assessing lung structure and function in both healthy individuals and patients with a range of lung conditions. It aims to improve understanding of these diseases and responses to treatments.See study design

What are the potential side effects?

As this trial involves MRI scanning using hyperpolarized xenon gas, side effects may be minimal but can include discomfort from lying still during the scan or feelings of claustrophobia. There are no known significant side effects from inhaling hyperpolarized xenon.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

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I have never had a respiratory infection or disease.

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I am between 18 and 85 years old.

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I am between 18-85 years old and have a diagnosed lung condition.

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I am between 18-85 years old with a diagnosed lung disease.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ 1-5 years

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~1-5 years

This trial's timeline: 3 weeks for screening, Varies for treatment, and 1-5 years for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Apparent Diffusion Coefficient (ADC)

Ventilation Defect Percent (VDP)

Secondary outcome measures

Signal-to-noise ratio (SNR)

Trial Design

1Treatment groups

Experimental Treatment

Group I: Patients with and without lung diseaseExperimental Treatment1 Intervention

All enrolled patients will undergo pulmonary function testing, questionnaires, 1H MRI, static ventilation and/or diffusion-weighted hyperpolarized 129Xe MRI and sputum induction at one or more timepoints over five years.

0 / 4Eligibility criteria met

Find a Location

Who is running the clinical trial?

McMaster UniversityLead Sponsor

881 Previous Clinical Trials

2,597,826 Total Patients Enrolled

St. Joseph's Healthcare HamiltonOTHER

196 Previous Clinical Trials

25,484 Total Patients Enrolled

Parameswaran Nair, MD, PhDPrincipal InvestigatorMcMaster University

7 Previous Clinical Trials

197 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Who is eligible to participate in this research experiment?

"Candidates for this trial must have alpha 1-antitrypsin deficiency and be aged between 18 to 85. In total, 60 people are sought after by the clinical study team."

Answered by AI

How many participants are being welcomed into this research initiative?

"Affirmative, clinicaltrials.gov confirms that this medical trial is in the midst of recruiting patients. This particular study was launched on April 19th 2018 and last updated September 7th 2022 with a goal of enrolling 60 individuals at one location."

Answered by AI

Are octogenarians being recruited to this trial?

"This trial requests that potential participants are aged between 18 to 85. Conversely, there are 207 separate clinical trials for persons below the age of majority and 796 for those beyond 65 years old."

Answered by AI

Is the research team currently recruiting participants?

"Affirmative. According to clinicaltrials.gov, applications are actively being accepted for this research project which first opened on April 19th 2018 and was last updated on September 7th 2022. Sixty people will be recruited from a single medical facility."

Answered by AI