Hyperpolarized 129Xe MRI for Lung Diseases

1
Effectiveness
1
Safety
Firestone Institute for Respiratory Health, St. Joseph's Healthcare, Hamilton, Canada
Lung Diseases+11 More
Hyperpolarized 129Xe MRI - Other
Eligibility
18+
All Sexes
Eligible conditions
Lung Diseases

Study Summary

Exploring the Utility of Hyperpolarized 129Xe MRI in Healthy Volunteers and Patients With Lung Disease

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Eligible Conditions

  • Lung Diseases
  • Airflow Obstruction, Chronic
  • Bronchiectasis
  • Asthma
  • Bronchopulmonary Dysplasia
  • Sarcoidosis, Pulmonary
  • Emphysema
  • Pulmonary Fibrosis
  • alpha 1-Antitrypsin Deficiency
  • Lung Diseases, Obstructive
  • Sarcoidosis
  • Pulmonary Disease, Chronic Obstructive
  • Chronic Obstructive Pulmonary Disease (COPD)
  • Alpha 1-Antitrypsin Deficiency

Treatment Effectiveness

Study Objectives

This trial is evaluating whether Hyperpolarized 129Xe MRI will improve 2 primary outcomes and 1 secondary outcome in patients with Lung Diseases. Measurement will happen over the course of 1-5 years.

1-5 years
Apparent Diffusion Coefficient (ADC)
Signal-to-noise ratio (SNR)
Ventilation Defect Percent (VDP)

Trial Safety

Trial Design

2 Treatment Groups

Control
Patients with and without lung disease

This trial requires 60 total participants across 2 different treatment groups

This trial involves 2 different treatments. Hyperpolarized 129Xe MRI is the primary treatment being studied. Participants will all receive the same treatment. There is no placebo group. The treatments being tested are not being studied for commercial purposes.

Patients with and without lung disease
Other
All enrolled patients will undergo pulmonary function testing, questionnaires, 1H MRI, static ventilation and/or diffusion-weighted hyperpolarized 129Xe MRI and sputum induction at one or more timepoints over five years.
ControlNo treatment in the control group

Trial Logistics

Trial Timeline

Approximate Timeline
Screening: ~3 weeks
Treatment: Varies
Reporting: 1-5 years
This trial has the following approximate timeline: 3 weeks for initial screening, variable treatment timelines, and roughly 1-5 years for reporting.

Who is running the study

Principal Investigator
P. N.
Prof. Parameswaran Nair, Professor of Medicine
McMaster University

Closest Location

Firestone Institute for Respiratory Health, St. Joseph's Healthcare - Hamilton, Canada

Eligibility Criteria

This trial is for patients born any sex aged 18 and older. There are 7 eligibility criteria to participate in this trial as listed below.

Mark “yes” if the following statements are true for you:
If you have a diagnosis of lung disease, you may be eligible for our pulmonary rehabilitation program. show original
People aged 18-85 years who have a lung disease, including but not limited to asthma, emphysema, COPD, bronchiectasis, sarcoidosis, pulmonary fibrosis, alpha 1-anti-trypsin deficiency, eosinophilic granulomatosis with polyangiitis, and bronchopulmonary dysplasia. show original
form The subject understands the study and is willing to participate in it, as evidenced by the signature on the consent form. show original
I can read and/or understand English. show original
old The study is looking for subjects who are male or female and who are aged between 18 and 85 years old. show original
No history of lung problems No current respiratory infection She has no current respiratory infection and no history of respiratory infection or disease. show original
Subject is judged to be in otherwise stable health on the basis of medical history

Patient Q&A Section

Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is lung diseases?

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Lung diseases are illnesses that cause loss of normal lung function and can affect the patient's daily life, health care professionals' work performance and death rate. The number of lung diseases in children has been increasing, mainly due to higher cigarette smoking rates. The diagnosis and treatment of lung diseases still face numerous problems.

Unverified Answer

Can lung diseases be cured?

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No cure for lung diseases exists, although many advances have been made in the understanding of the disease processes over the past few decades. Many trials have focused on treatment of advanced or incurable lung diseases. Because all lung diseases have devastating consequences, there remains a need for better understanding of disease mechanisms and potential treatments for lung diseases.

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What causes lung diseases?

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Some of the risk factors for lung diseases include exposure to pesticides, smoking, occupational exposure, and environmental exposures like air pollution. Lung diseases also develop when specific immune cells and/or cells in the airway are triggered or are unable to perform appropriate functions.

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How many people get lung diseases a year in the United States?

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Approximately 60,200 people die from lung diseases and 1.5 million are hospitalized for lung disease each year in the United States. Mortality and hospitalization from lung diseases could be reduced by 20%.

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What are the signs of lung diseases?

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Diagnosis of lung conditions (including [diseases that affect how people breathe, like lung cancer, emphysema, and chronic obstructive pulmonary disease (COPD)] are [important because these conditions often lead to permanent morbidity and sometimes even to death] in adults involves various methods (such as physical examination, spirometry, X-rays etc.) that often use quantitative measurements of air leak and gas exchange in the lungs.

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What are common treatments for lung diseases?

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Findings from a recent study has highlighted the need for adequate lung disease treatments which are generally targeted at specific disease stages. Effective lung patient education regarding diagnosis, prevention and progression and the use of lung disease medications need to be emphasized to improve the health status of patients. Additionally, as lung disease treatments become more effective, patients will require less frequent visits by their healthcare providers, fewer visits from external health care providers and fewer lung disease medications to manage lung diseases.

Unverified Answer

Is hyperpolarized 129xe mri typically used in combination with any other treatments?

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Combinations of hyperpolarized mri with any other treatments may lead to increased specificity and decreased sensitivity, which may in turn reduce the accuracy of distinguishing lung tuberculosis from other disease states.

Unverified Answer

Has hyperpolarized 129xe mri proven to be more effective than a placebo?

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Hyperpolarized magnetic resonance imaging using P-mRI was found to be more effective than a placebo for all 4 MR techniques which demonstrated increased lesion contrast, improved conspicuity of vascular enhancement images, and increased overall image quality.

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What is the latest research for lung diseases?

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The main aim of research in this field nowadays is to understand the cellular mechanisms behind inflammatory and fibrotic lung diseases, in a bid to identify novel therapeutic targets for these pathologies. Lung cancer is an incurable disease and is the main cause of death worldwide. The mechanisms that cause lung cancer have long been unknown and new understanding of the lung immunology is needed to facilitate research that would lead to new treatments for lung cancer. Lung diseases have a global burden; research in lung immunology could have a big impact on the understanding of lung immunopathology and treatment strategies against lung diseases would change in future.

Unverified Answer

How serious can lung diseases be?

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Several lung diseases are common and a number of fatal diseases are lethal. The major cause of lung diseases is smoking, which is associated with lung cancer, COPD, bronchiectasis and asthma and chronic lung disease. Lung diseases which can be life threatening are [Pneumoconiosis], [Argentinian hemorrhagic fever] and [Pleurisy] although there are many other ones. In a global perspective, lung diseases are an important public health problem because they cause premature death and disability. Patients with lung diseases benefit from supportive medical therapies which are crucial in enhancing quality of life, enabling patients to continue with activities of daily living and maintain and restore functional capacities.

Unverified Answer

What is the primary cause of lung diseases?

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The causes of lung diseases may be divided into chronic inflammatory, fibrotic, autoimmune, external factors, and unknown causes. Lung diseases appear to have a complex mechanism, requiring multiple factors for disease development. The major part of chronic inflammatory lung diseases is due to non-infectious and -allergic diseases, which cause chronic immune activation that drives the remodeling and fibrosis of the lung.

Unverified Answer

What is hyperpolarized 129xe mri?

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(129) xe-mri can be performed successfully with minimal risk to the patient after adequate training and experience. A high number of patients underwent hyperpolarized (129) xe-mri examinations. (129) xe-mri may be useful in clinical practice to evaluate pulmonary edema by detecting the distribution of (3) H.

Unverified Answer
See if you qualify for this trial
Get access to this novel treatment for Lung Diseases by sharing your contact details with the study coordinator.