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Topiramate for Schizophrenia
Study Summary
This trial will study whether topiramate can help improve symptoms and cause weight loss in people with schizophrenia who haven't responded to other treatments and are taking clozapine.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowTimeline
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Side effects data
From 2017 Phase 4 trial • 282 Patients • NCT02191579Trial Design
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- I have a history of glaucoma.I have been on Clozapine for 12 weeks or more at a high dose or with high blood levels.You are currently at risk of harming yourself or having thoughts of suicide.I have liver or kidney problems.I have had kidney stones in the past.I am of childbearing age and not using contraception, or I am nursing.I have a serious heart, blood, lung, or hormone-related condition that is not under control.I haven't started new diabetes or cholesterol medication in the last 2 months.I am currently taking hydrochlorothiazide.My HbA1c level is above 9%, or I have severe symptoms of high blood sugar.Topiramate was ineffective or caused side effects for me.I am between 17 and 59 years old.I have not had any major medical or surgical events in the last 3 months.I have changed my antipsychotic medication in the last 3 months.I am taking medication that reduces fluid production in my body.I am currently being treated with Valproic Acid.You have a problem with drinking alcohol.I have been diagnosed with schizophrenia or schizoaffective disorder.You have significant impairments in your daily functioning or your overall ability to function well.
- Group 1: Topiramate
- Group 2: Placebo
- All Individual Drugs Already Approved - Therapies where all constituent drugs have already been approved are likely to have better-understood side effect profiles.
- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
Has Topiramate been scrutinized in other scientific investigations?
"Currently, 18 studies are underway to explore the potential of Topiramate. Of those ongoing investigations, 3 have advanced to Phase 3. Most trials for this medication are located in Sherbrooke, Quebec; however there is an additional 30 research sites across North America also running tests with Topiramate."
Are there opportunities to enroll in this research study at the present moment?
"According to the clinicaltrials.gov entry, this medical trial is actively searching for participants and was first published on May 1st 2016 with its most recent update occurring on June 18th 2021."
How many participants is the maximum capacity for this clinical experiment?
"Affirmative. Clinicaltrials.gov's listings indicate that this clinical study is still recruiting, with an initial posting of May 1st 2016 and a most recent update occurring on June 18th 2021. 50 people are needed to be enrolled from one single medical site."
Are elderly individuals eligible for participation in this investigation?
"The eligibility criteria mandate that all enrollees must be aged between 17 and 59."
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