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Cognitive Remediation (CR) for Schizophrenia (MCT Trial)

N/A

Waitlist Available

Led By Mahesh Menon, PhD, RPsych

Research Sponsored by University of British Columbia

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be between 18 and 65 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up 8-12 weeks (post-treatment)

Awards & highlights

MCT Trial Summary

This trial seeks to compare the effectiveness of two different types of therapies, metacognitive training (MCT) and cognitive remediation (CR), at treating the persistent positive and cognitive symptoms of schizophrenia. MCT is a therapy designed to improve patient awareness and insight into the cognitive biases that are frequently seen in schizophrenia, while CR is a therapy designed to improve performance in a variety of neurocognitive functions. Both therapies will be compared to treatment as usual (TAU) to assess their effectiveness.

Eligible Conditions

Schizophrenia
Psychosis
Schizoaffective Disorder
Schizophreniform Disorder

MCT Trial Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ 8-12 weeks (post-treatment)

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~8-12 weeks (post-treatment)

This trial's timeline: 3 weeks for screening, Varies for treatment, and 8-12 weeks (post-treatment) for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Delusion Severity

Secondary outcome measures

Cognitive Bias

Cognitive Function

Feasibility and acceptability

+3 more

MCT Trial Design

3Treatment groups

Experimental Treatment

Active Control

Group I: Metacognitive Training for PsychosisExperimental Treatment1 Intervention

Individuals with psychosis (Schizophrenia, Schizoaffective, Schizophreniform, etc.) who will receive Metacognitive Training twice weekly for 8 weeks (16 sessions).

Group II: Cognitive Remediation for PsychosisExperimental Treatment1 Intervention

Individuals with psychosis (Schizophrenia, Schizoaffective, Schizophreniform, etc.) who will receive Cognitive Remediation treatment twice weekly for 8 weeks (16 sessions).

Group III: Treatment as Usual for PsychosisActive Control1 Intervention

Individuals with psychosis (Schizophrenia, Schizoaffective, Schizophreniform, etc.) who will continue to receive treatment as usual (TAU) as defined by their health care team (i.e., medication, other therapies) while still taking part in baseline, midpoint, and end-point assessments.

Treatment

First Studied

Drug Approval Stage

How many patients have taken this drug

Cognitive Remediation (CR)

2010

N/A

~40

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