← Back to Search

Radiation Therapy

Radiotherapy Schedules for High Risk Prostate Cancer

Q: Is enrollment presently open for this research study?

<p>Registrations for this medical trial have been closed, as indicated on clinicaltrials.gov where the study was first posted in June 2011 and last updated in March 2022. Nevertheless, there are currently 1321 other trials that are actively recruiting participants.</p>

N/A

Waitlist Available

Research Sponsored by Dr. Patrick Cheung

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

T1-2 N0 M0, Gleason Score <= 7, PSA 20 - 100

T1-2 N0 M0, Gleason Score 8 - 10, PSA <= 100

Timeline

Screening 3 weeks

Treatment Varies

Follow Up at 5 years

Awards & highlights

Study Summary

This trial is testing whether a different radiotherapy schedule can reduce side effects in patients with high risk prostate cancer.

Who is the study for?

This trial is for men with high-risk, localized prostate cancer. Eligible participants have a Gleason Score of 7-10 and PSA levels up to 100, without spread to lymph nodes or distant organs. Men with hip replacements, certain genetic disorders like ataxia telangiectasia, active inflammatory diseases, or previous pelvic radiotherapy cannot join.Check my eligibility

What is being tested?

The study compares two radiation therapy schedules: conventional fractionation (standard doses over a longer period) versus hypofractionated boost (higher doses in a shorter period). The main goal is to see which method causes fewer short-term side effects.See study design

What are the potential side effects?

Potential side effects include skin reactions in the treated area, fatigue, urinary issues such as increased frequency or discomfort during urination, bowel changes like diarrhea or rectal bleeding, and erectile dysfunction.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Select...

My prostate cancer is early stage, with a low Gleason score and a PSA level between 20-100.

Select...

My prostate cancer is early stage, aggressive, and my PSA is 100 or less.

Select...

My prostate cancer is at stage T3 N0 M0, with any Gleason score and a PSA of 100 or less.

Select...

My prostate cancer diagnosis was confirmed through a tissue examination.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ at 5 years

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~at 5 years

This trial's timeline: 3 weeks for screening, Varies for treatment, and at 5 years for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Acute Toxicity

Secondary outcome measures

Biochemical Control (Phoenix Definition)

Late Toxicity

Overall Survival

Trial Design

2Treatment groups

Experimental Treatment

Active Control

Group I: HypofractionationExperimental Treatment1 Intervention

Using a one phase IMRT plan, the pelvic lymph nodes will be treated to a dose of 48 Gy in 25 fractions, while the prostate will be treated to a dose of 68 Gy in 25 fractions concomitantly (simulataneous integrated boost).

Group II: Standard FractionationActive Control1 Intervention

Using 2 sequential IMRT plans, the pelvic lymph nodes and prostate will initially be treated to 46 Gy in 23 fractions, followed by a subsequent boost to the prostate to a total dose of 78 Gy.

0 / 4Eligibility criteria met

Find a Location

Who is running the clinical trial?

Dr. Patrick CheungLead Sponsor

1 Previous Clinical Trials

Patrick Cheung, MDStudy ChairToronto Sunnybrook Regional Cancer Centre

2 Previous Clinical Trials

262 Total Patients Enrolled

2 Trials studying Prostate Cancer

262 Patients Enrolled for Prostate Cancer

Media Library

Conventionally Fractionated Boost (Radiation Therapy) Clinical Trial Eligibility Overview. Trial Name: NCT03526510 — N/A

$Prostate Cancer Research Study Groups: Standard Fractionation, Hypofractionation$

Prostate Cancer Clinical Trial 2023: Conventionally Fractionated Boost Highlights & Side Effects. Trial Name: NCT03526510 — N/A

Conventionally Fractionated Boost (Radiation Therapy) 2023 Treatment Timeline for Medical Study. Trial Name: NCT03526510 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is enrollment presently open for this research study?

"Registrations for this medical trial have been closed, as indicated on clinicaltrials.gov where the study was first posted in June 2011 and last updated in March 2022. Nevertheless, there are currently 1321 other trials that are actively recruiting participants."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Hypofractionated Boost vs Conventionally Fractionated Boost for Localized High Risk Prostate Cancer

Dr. Patrick Cheung 2011. "Hypofractionated Boost vs Conventionally Fractionated Boost for Localized High Risk Prostate Cancer". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT03526510.

All > Mens Health