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Healthy obese children for Prader-Willi Syndrome

N/A
Waitlist Available
Led By Andrea Haqq, MD
Research Sponsored by Duke University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be younger than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up baseline
Awards & highlights

Study Summary

The hyperghrelinemia of children with PWS provides a unique model by which to explore the hormonal and metabolic effects of orexigenic hormones in normal and pathologic conditions. An important question to be addressed by this proposed research includes the macro-nutrient regulation of ghrelin and PYY in obese children and children with PWS. As ghrelin antagonists are considered potential future anti-obesity agents, it is essential to gain understanding of the developmental, nutritional and hormonal regulation of this important orexigenic hormone in children.

Eligible Conditions
  • Prader-Willi Syndrome
  • Obesity

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~4 hours
This trial's timeline: 3 weeks for screening, Varies for treatment, and 4 hours for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Change in PYY concentrations
Change in ghrelin levels
Secondary outcome measures
Fasting Insulin-like growth factor 1 (IGF-1) levels
Gastric inhibitory polypeptide (GIP)
Glucagon-like peptide-1 (GLP-1)
+1 more

Trial Design

2Treatment groups
Experimental Treatment
Group I: Healthy obese childrenExperimental Treatment2 Interventions
High carbohydrate meal High fat meal
Group II: Children with Prader Willi SyndromeExperimental Treatment2 Interventions
High carbohydrate meal High fat meal

Find a Location

Who is running the clinical trial?

Duke UniversityLead Sponsor
2,377 Previous Clinical Trials
3,427,138 Total Patients Enrolled
3 Trials studying Prader-Willi Syndrome
30,015 Patients Enrolled for Prader-Willi Syndrome
National Institutes of Health (NIH)NIH
2,716 Previous Clinical Trials
7,510,995 Total Patients Enrolled
3 Trials studying Prader-Willi Syndrome
39 Patients Enrolled for Prader-Willi Syndrome
Canadian Institutes of Health Research (CIHR)OTHER_GOV
1,348 Previous Clinical Trials
26,455,680 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
clinicaltrials.govStudy
Macronutrient Regulation of Ghrelin and Peptide YY
2004. "Macronutrient Regulation of Ghrelin and Peptide YY". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT02464514.
~1 spots leftby May 2025
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