Protease Enzyme Supplement for Postprandial Amino Acid Levels
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial tests a special enzyme supplement called P24 to determine its effect on amino acid levels in the blood after consuming a mixed-protein meal. Researchers aim to understand how this supplement influences hormones related to digestion, blood sugar levels, and feelings of hunger and fullness. The trial compares the enzyme supplement to a placebo (a pill with no active ingredient) to identify any real effects. Healthy adults willing to consume a specific protein meal and without digestive issues or diabetes might be suitable for this study. As an unphased trial, this study offers participants the opportunity to contribute to foundational research that could lead to new dietary supplements.
Will I have to stop taking my current medications?
If you are currently using medications or supplements that affect glucose metabolism or digestion, you may need to stop taking them to participate in this trial.
Is there any evidence suggesting that this treatment is likely to be safe for humans?
Research has shown that P24, a supplement containing a special enzyme, breaks down protein more effectively. This can enhance the body's use of amino acids, the building blocks of protein. Previous studies have demonstrated that P24 aids in protein digestion and increases amino acid availability without major safety concerns.
P24 is generally considered safe, with no reports of serious side effects in studies. People who have taken similar enzyme supplements have tolerated them well, suggesting that P24 is likely safe for most individuals. However, individual experiences can vary. It is always important to consult a healthcare professional before starting any new supplement, especially if existing health conditions are present.12345Why are researchers excited about this trial?
Unlike standard treatments for boosting postprandial amino acid levels, which typically involve dietary adjustments or amino acid supplements, the P24 supplement offers a novel approach. P24 is an acid-active protease enzyme that is taken as a capsule before meals. This enzyme aids digestion by breaking down proteins more efficiently, potentially enhancing amino acid absorption without altering diet. Researchers are excited about P24 because it targets protein digestion directly, offering a new mechanism that could improve nutrient absorption quickly and effectively.
What evidence suggests that the P24 enzyme supplement could be effective for postprandial amino acid levels?
This trial will compare the effects of the protease enzyme supplement P24 with a placebo. Studies have shown that supplements like P24, which contain enzymes that aid in protein breakdown, can enhance protein digestion. This suggests that P24 might increase protein absorption from meals, providing more amino acids for the body. Research indicates that P24 can facilitate protein digestion, particularly when consumed with other protein-rich foods. Evidence also suggests that these supplements can influence bodily responses to meals, affecting hunger and satiety. While research continues, early findings suggest that P24 could improve protein absorption.23467
Who Is on the Research Team?
Roberta H Holt, PhD
Principal Investigator
University of California, Davis
Are You a Good Fit for This Trial?
This trial is for healthy adults aged 45-75 with a BMI between 18.5 and 35 who are willing to eat a test meal and can follow study instructions.Inclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive either the P24 enzyme supplement or placebo during two test visits, separated by a 7-day washout period
Follow-up
Participants are monitored for safety and effectiveness after treatment
What Are the Treatments Tested in This Trial?
Interventions
- P24
Trial Overview
The study compares the effects of a protease enzyme supplement (P24) versus placebo on how the body processes amino acids after eating a mixed-protein meal. Participants receive either P24 or placebo in this controlled setting.
How Is the Trial Designed?
2
Treatment groups
Experimental Treatment
Placebo Group
P24 is an acid-active protease enzyme supplement administered as one capsule prior to the standardized mixed-protein burger meal. The active product contains P24 and is compared with a matching placebo capsule in a randomized, double-blind crossover design in healthy adults
Matching placebo capsule containing microcrystalline cellulose, administered prior to the standardized mixed-protein burger meal. Placebo capsules are identical in appearance to the active product and are used to maintain blinding in the randomized crossover design.
Find a Clinic Near You
Who Is Running the Clinical Trial?
Amplifye
Lead Sponsor
Citations
Acute Microbial Protease Supplementation Increases Net ...
Microbial protease supplementation may be a strategy for improving protein digestion and subsequent postprandial plasma amino acid availability.
Effects of P24 on Postprandial Aminoacidemia
The purpose of this study is to quantify the acute effects of an acid-active protease enzyme supplement (P24) on postprandial aminoacidemia following ...
3.
withpower.com
withpower.com/trial/phase-postprandial-amino-acid-concentrations-in-healthy-adults-4-2026-6ca0fProtease Enzyme Supplement for Postprandial Amino Acid ...
The purpose of this study is to quantify the acute effects of an acid-active protease enzyme supplement (P24) on postprandial aminoacidemia ...
Acute Effects of Oral Microbial Protease Co-ingestion with ...
Co-ingestion of WPC with P3 can enhance early postprandial plasma aminoacidemia and alter select indices of appetite and satiety in young adults.
Effects of P24 on Postprandial Aminoacidemia
The purpose of this study is to quantify the acute effects of an acid-active protease enzyme supplement (P24) on postprandial aminoacidemia ...
Acid-active proteases to optimize dietary protein digestibility
Data from this comprehensive enzymatic evaluation support the benefits of P24's activity toward enhancing protein digestion and bioavailability, ...
7.
trial.medpath.com
trial.medpath.com/clinical-trial/9f59cf25607d5311/nct07479173-acid-active-protease-p24-postprandial-aminoacidemia-burger-meal-healthy-adultsEffects of P24 on Postprandial Aminoacidemia | MedPath
The purpose of this study is to quantify the acute effects of an acid-active protease enzyme supplement (P24) on postprandial aminoacidemia following ...
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