TRP-2 Urine Dipstick for Acute Pancreatitis

Overseen By Nicholas Zyromski, MD

Age: 18+

Sex: Any

Trial Phase: Academic

Sponsor: Indiana University

Disqualifiers: Pregnancy, Prisoner, others

No Placebo Group All trial participants will receive the active study treatment (no placebo)

Compensation: Varies

Number of Visits: 2

50 Participants Needed

Trial Summary

What is the purpose of this trial?

The goal of this study is to learn if urine trypsinogen can be used to diagnose post-pancreatectomy acute pancreatitis in patients undergoing pancreatectomy. Participants will have their urine measured by dipsticks during and after their surgery.

Do I need to stop my current medications for this trial?

The trial information does not specify whether you need to stop taking your current medications.

What data supports the effectiveness of the TRP-2 Urine Dipstick treatment for acute pancreatitis?

The TRP-2 Urine Dipstick test is shown to be a useful tool for diagnosing acute pancreatitis by measuring trypsinogen-2 levels in urine, which helps predict the severity of the condition. This rapid test can identify patients at risk of severe pancreatitis, allowing for early treatment and potentially better outcomes. ^{1 2 3 4 5}

How does the TRP-2 urine dipstick test differ from other treatments for acute pancreatitis?

The TRP-2 urine dipstick test is unique because it offers a rapid and non-invasive way to diagnose acute pancreatitis by detecting trypsinogen-2 in urine, unlike traditional methods that rely on blood tests for enzymes like amylase and lipase. ^{1 2 6 7 8}

Eligibility Criteria

This trial is for patients undergoing pancreatectomy, a surgical procedure to remove the pancreas. It aims to see if urine trypsinogen-2 (TRP-2) can help diagnose acute pancreatitis after surgery. Specific eligibility criteria are not provided.

Inclusion Criteria

I am older than 18.

I am scheduled for elective surgery to remove my pancreas.

Exclusion Criteria

Pregnant women

Prisoner

I am under 18 years old.

Timeline

Screening

Participants are screened for eligibility to participate in the trial

1-2 weeks

Preoperative

Patients are identified and educated about possible enrollment in the study during preoperative scheduling and clinic visits

1 day

1 visit (in-person)

Intraoperative and Immediate Postoperative

Urine Trypsinogen-2 is measured preoperatively, intraoperatively, and in the post-anesthesia recovery unit

Day of surgery

1 visit (in-person)

Postoperative Monitoring

Urine Trypsinogen-2 is measured on postoperative days 1, 2, and 3 to detect PPAP

3 days

Daily monitoring (in-person)

Follow-up

Participants are monitored for safety and effectiveness after treatment

4 weeks

Treatment Details

Interventions

• TRP-2 Urine Dipstick

Trial Overview The study is testing whether TRP-2 levels in urine, measured using dipsticks during and after pancreatectomy, can be an effective tool for early detection of post-surgery acute pancreatitis.

Participant Groups

Group I: Pancreatectomy Patients Experimental Treatment 1 Intervention

Patients who underwent pancreatectomy and are having their urine dipstick tested for Trypsinogen-2

Who Is Running the Clinical Trial?

Indiana University

Lead Sponsor

Trials

1,063

Recruited

1,182,000+

References

1. United States pubmed.ncbi.nlm.nih.gov

Repeated Negative Urine Trypsinogen-2 Dipstick Test Rules Out Diagnosis of Post-ERCP Pancreatitis. [2021]

2. United States pubmed.ncbi.nlm.nih.gov

Usefulness of urinary trypsinogen-2 and trypsinogen activation peptide in acute pancreatitis: A multicenter study in Japan. [2020]

3. United States pubmed.ncbi.nlm.nih.gov

Urinary trypsinogen-2 dipstick in acute pancreatitis. [2009]

4. United States pubmed.ncbi.nlm.nih.gov

Urinary trypsinogen activation peptide (TAP) predicts severity in patients with acute pancreatitis. [2019]

5. England pubmed.ncbi.nlm.nih.gov

Predicting the severity of acute pancreatitis by rapid measurement of trypsinogen-2 in urine. [2019]

6. Turkey pubmed.ncbi.nlm.nih.gov

The role of urine trypsinogen-2 test in the differential diagnosis of acute pancreatitis in the Emergency Department. [2010]

7. United States pubmed.ncbi.nlm.nih.gov

Rapid urinary trypsinogen-2 test strip in the diagnosis of acute pancreatitis. [2019]

8. England pubmed.ncbi.nlm.nih.gov

Effectivity of qualitative urinary trypsinogen-2 measurement in the diagnosis of acute pancreatitis: a randomized, clinical study. [2019]