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Deprescribing Intervention for Overmedication
N/A
Waitlist Available
Led By Lisa Herrinton, PhD
Research Sponsored by Kaiser Permanente
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
Be older than 65 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up difference between (days 181-365 after randomization) and (180 days before randomization)
Awards & highlights
Study Summary
This trial tested a quality intervention intended to reduce hyperpolypharmacy in older patients, potentially reducing adverse effects. Results showed changes in medications and geriatric syndrome, and monitored utilization and withdrawal effects.
Who is the study for?
This trial is for Kaiser Permanente patients aged 76 or older who are taking 10 or more prescription medications. Candidates must have filled their prescriptions at least twice in the past year and most recently within the last six months. Those with less than a year's enrollment, no primary care practitioner, on dialysis, in hospice, recent cancer treatment, or organ transplant history are excluded.Check my eligibility
What is being tested?
The study tests a deprescribing intervention to reduce medication use among elderly patients overmedicated with prescription drugs. It involves collaboration between doctors and pharmacists to manage drug therapy by phone over several cycles up to 180 days. The main goal is to see if this can decrease medication numbers and geriatric syndrome prevalence.See study design
What are the potential side effects?
Potential side effects may include adverse reactions from reducing medications such as withdrawal symptoms or changes in health status due to alterations in drug therapy. These will be monitored through patient utilization patterns and recorded health data.
Timeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ difference between (days 181-365 after randomization) and (180 days before randomization)
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~difference between (days 181-365 after randomization) and (180 days before randomization)
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Primary outcome measures
Pharmaceutical Preparations
Syndrome
Secondary outcome measures
Utilization
Other outcome measures
Adverse drug withdrawal effects
Trial Design
2Treatment groups
Experimental Treatment
Active Control
Group I: Bundled hyperpolypharmacy interventionExperimental Treatment1 Intervention
Eligible participants with physician authorization who are randomly assigned to intervention
Group II: ControlActive Control1 Intervention
Eligible participants with physician authorization who are randomly assigned to usual care
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Who is running the clinical trial?
Kaiser PermanenteLead Sponsor
538 Previous Clinical Trials
24,111,357 Total Patients Enrolled
Lisa Herrinton, PhDPrincipal InvestigatorKaiser Permanente
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Eligibility Criteria:
This trial includes the following eligibility criteria:- You have had a heart, liver, lung, breast, or bone marrow transplant in the past.
Research Study Groups:
This trial has the following groups:- Group 1: Bundled hyperpolypharmacy intervention
- Group 2: Control
Awards:
This trial has 1 awards, including:- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
Timeline:
This trial has the following timeline:- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Are any volunteers needed for this medical trial at present?
"This clinical trial, initially posted on October 19th 2020 and recently updated on November 14th 2022, is not currently seeking applicants. Fortunately, 23 other medical studies are actively recruiting patients at this time."
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