Air Pollution Exposure and Risk of ADHD in Youth
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial aims to explore how air pollution during pregnancy might affect the risk of ADHD, a condition characterized by inattention and hyperactivity, in children. Researchers are particularly interested in the roles of maternal inflammation during pregnancy and children's sleep issues. Participants will undergo MRI scans to further understand these connections. Families who participated in a specific birth study and speak English or Spanish may be suitable, especially if they have no serious neurological disorders or issues with MRI machines. As an unphased trial, this study offers a unique opportunity to contribute to groundbreaking research on environmental impacts on child health.
Will I have to stop taking my current medications?
The trial information does not specify whether you need to stop taking your current medications.
What prior data suggests that the MRI task is safe for participants?
Research shows that MRI tasks, like those in this study, are generally safe for participants. MRI, or magnetic resonance imaging, is a common tool in medical research and practice. It uses strong magnets and radio waves to create images of the body's interior without radiation. Studies have found that most people handle MRIs well and usually do not experience side effects.
Some individuals might feel uncomfortable in the MRI machine due to the small space, but this is typically the only discomfort. Participants with metal implants or devices should inform the researchers, as MRI might not be suitable. Overall, participating in an MRI study is considered safe for most people.
Why are researchers excited about this trial?
Researchers are excited about this trial because it explores the potential link between air pollution exposure and ADHD in youth using MRI tasks. Unlike traditional treatments for ADHD, which often involve medication like stimulants that target neurotransmitters, this trial utilizes MRI technology to investigate how environmental factors may influence brain activity related to ADHD. By focusing on this innovative approach, researchers hope to uncover new insights into the environmental contributions to ADHD, potentially leading to better prevention and intervention strategies.
What evidence suggests that this study's methods could be effective in understanding the risk of ADHD related to air pollution exposure?
This study does not test a treatment but explores how prenatal air pollution exposure might affect the risk of ADHD in children. Research has shown that exposure to air pollution during pregnancy can cause inflammation and other issues that might impact a child's brain development. Some studies suggest this could increase the risk of ADHD. Using MRI scans, researchers aim to identify any brain changes related to pollution exposure. This could clarify if and how air pollution affects the risk of ADHD.
Who Is on the Research Team?
Claudia I Lugo-Candelas, PhD
Principal Investigator
Columbia University Irving Medical Center/New York State Psychiatric institute
Cristiane S Duarte, PhD
Principal Investigator
Columbia University Irving Medical Center/New York State Psychiatric institute
Glorisa Canino, PhD
Principal Investigator
University of Puerto Rico
Are You a Good Fit for This Trial?
This study is for children enrolled in the Boricua Youth Study (BYS-ECHO) and their parents who can consent to participation. Participants must speak English or Spanish. It excludes those with serious neurological disorders, MRI contraindications like metal implants, claustrophobia, or if a parent cannot legally consent.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Neuroimaging Study
Participants undergo neuroimaging to assess the impact of prenatal air pollution exposure on neurodevelopment
Follow-up
Participants are monitored for neurodevelopmental outcomes and ADHD risk
What Are the Treatments Tested in This Trial?
Interventions
- MRI task
Find a Clinic Near You
Who Is Running the Clinical Trial?
New York State Psychiatric Institute
Lead Sponsor
University of Puerto Rico
Collaborator
National Institute of Environmental Health Sciences (NIEHS)
Collaborator