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procalcitonin for Bacterial Pneumonia (ProSAVE Trial)

N/A
Waitlist Available
Led By Michael K Mansour, MD, PhD
Research Sponsored by Massachusetts General Hospital
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 30 days
Awards & highlights

ProSAVE Trial Summary

This trial will compare PCT-guided antibiotic prescription (by a Stewardship Team) to standard guidelines, in hospitalized adult patients with suspected or confirmed LRTI.

ProSAVE Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~30 days
This trial's timeline: 3 weeks for screening, Varies for treatment, and 30 days for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Primary objective
Short treatment of pneumonia
Secondary outcome measures
Antibiotic exposure at discharge
Composite safety adverse event rate
Days of therapy per 1000 patient days
+2 more
Other outcome measures
Clostridium difficile infection (CDI)
Healthcare economic endpoints

ProSAVE Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: Procalcitonin algorithm+stewardship teamExperimental Treatment1 Intervention
antibiotic prescription guided by PCT values
Group II: standard groupActive Control1 Intervention
standard of care guided by current guidelines
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
procalcitonin
2010
N/A
~760

Find a Location

Who is running the clinical trial?

B·R·A·H·M·S GmbH , part of Thermo Fisher ScientificUNKNOWN
Massachusetts General HospitalLead Sponsor
2,928 Previous Clinical Trials
13,197,655 Total Patients Enrolled
2 Trials studying Bacterial Pneumonia
325 Patients Enrolled for Bacterial Pneumonia
Michael K Mansour, MD, PhDPrincipal InvestigatorMassachusetts General Hospital

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
clinicaltrials.govStudy
PROcalcitonin Impact on Antibiotic Reduction, adverSe Events and AVoidable healthcarE Costs (ProSAVE): A RCT
Michael K. Mansour 2020. "PROcalcitonin Impact on Antibiotic Reduction, adverSe Events and AVoidable healthcarE Costs (ProSAVE): A RCT". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT04158804.
~145 spots leftby Apr 2025
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