Manual aspiration for Pleural Effusion

Phase-Based Progress Estimates
1
Effectiveness
1
Safety
University of Minnesota, Minneapolis, MN
Pleural Effusion
Wall suction - Procedure
Eligibility
18+
All Sexes
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Study Summary

Researchers will compare 3 standard of care methods of pleural fluid drainage during therapeutic thoracentesis. Patients are randomized to manual aspiration, vacuum bottle drainage or wall suction methods. Primary outcome is procedural time with secondary outcomes of pain and dyspnea scores.

Treatment Effectiveness

Effectiveness Progress

1 of 3

Study Objectives

9 Primary · 0 Secondary · Reporting Duration: Through study completion, an average of 24 hours

24 hours post-procedure
Pain and dyspnea scores- 24h post
5 minutes post-procedure
Pain and dyspnea scores- 5m post
Immediately after removing the thoracentesis catheter
Pain and dyspnea scores- Post-cath
Immediately prior to starting the thoracentesis
Pain and dyspnea scores- Baseline
Hour 24
Pain and dyspnea scores- Cath
Pain and dyspnea scores- Post-fluid
Procedural time to 1L
Procedural time to 500mL
Procedural time to 750mL

Trial Safety

Safety Progress

1 of 3

Trial Design

3 Treatment Groups

Manual aspiration
1 of 3
Wall suction
1 of 3
Vacuum bottle drainage
1 of 3
Active Control

102 Total Participants · 3 Treatment Groups

Primary Treatment: Manual aspiration · No Placebo Group · N/A

Manual aspiration
Procedure
ActiveComparator Group · 1 Intervention: Manual aspiration · Intervention Types: Procedure
Wall suction
Procedure
ActiveComparator Group · 1 Intervention: Wall suction · Intervention Types: Procedure
Vacuum bottle drainage
Procedure
ActiveComparator Group · 1 Intervention: Vacuum bottle drainage · Intervention Types: Procedure

Trial Logistics

Trial Timeline

Approximate Timeline
Screening: ~3 weeks
Treatment: Varies
Reporting: through study completion, an average of 24 hours
Closest Location: University of Minnesota · Minneapolis, MN
Photo of University of Minnesota   1Photo of University of Minnesota   2Photo of University of Minnesota  3
1993First Recorded Clinical Trial
1 TrialsResearching Pleural Effusion
828 CompletedClinical Trials

Eligibility Criteria

Age 18+ · All Participants · 3 Total Inclusion Criteria

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About The Reviewer

Michael Gill preview

Michael Gill - B. Sc.

First Published: October 9th, 2021

Last Reviewed: August 12th, 2022

Michael Gill holds a Bachelors of Science in Integrated Science and Mathematics from McMaster University. During his degree he devoted considerable time modeling the pharmacodynamics of promising drug candidates. Since then, he has leveraged this knowledge of the investigational new drug ecosystem to help his father navigate clinical trials for multiple myeloma, an experience which prompted him to co-found Power Life Sciences: a company that helps patients access randomized controlled trials.