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Cue-established expectations for Expectations

N/A

Waitlist Available

Led By Tor D Wager, PhD

Research Sponsored by Trustees of Dartmouth College

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be between 18 and 65 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up within trials, outcome ratings are collected pre-stimulus (4s window); trials are collected across 3 sessions. ratings are then averaged, reflecting: perceived pain as a function of low cue exposure.

Awards & highlights

Study Summary

This trial sequence is repeated 3 times for each condition, resulting in a total of 9 trials.

Eligible Conditions

Expectations
Placebo

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ within trials, outcome ratings are collected pre-stimulus (4s window); trials are collected across 3 sessions. ratings are then averaged, reflecting: perceived pain as a function of low cue exposure.

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~within trials, outcome ratings are collected pre-stimulus (4s window); trials are collected across 3 sessions. ratings are then averaged, reflecting: perceived pain as a function of low cue exposure.

This trial's timeline: 3 weeks for screening, Varies for treatment, and within trials, outcome ratings are collected pre-stimulus (4s window); trials are collected across 3 sessions. ratings are then averaged, reflecting: perceived pain as a function of low cue exposure. for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Behavioral: Within Participant Subjective Outcome Ratings of Acute Thermal Pain Following High Compared to Low Cues

Behavioral: Within Participant Subjective Outcome Ratings of Acute Thermal Pain Following High Cues

Behavioral: Within Participant Subjective Outcome Ratings of Acute Thermal Pain Following Low Cues

+6 more

Secondary outcome measures

Behavioral: Within Participant Expectation Ratings of Acute Thermal Pain Following High Compared to Low Cues

Behavioral: Within Participant Expectation Ratings of Cognitive Effort Following High Compared to Low Cues

Behavioral: Within Participant Expectation Ratings of Cognitive Effort Following High Cues

+10 more

Trial Design

1Treatment groups

Experimental Treatment

Group I: Cue-established expectationsExperimental Treatment3 Interventions

Prior to experiencing the stimuli from three tasks (somatic pain/cognitive effort/vicarious pain), the participant is presented with an expectancy cue. The cue depicts 10 data points on a semi-circular scale (0-180 degrees) with categorical labels ranging from "no effort" to "strongest effort of any kind." Subsequently, participants report expectation ratings and outcome ratings.

Treatment

First Studied

Drug Approval Stage

How many patients have taken this drug

Pain Expectancy Cues

2020

N/A

~140

Vicarious Pain Expectancy Cues

2020

N/A

~140

Cognitive Effort Expectancy Cues

2020

N/A

~140

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Who is running the clinical trial?

Trustees of Dartmouth CollegeLead Sponsor

23 Previous Clinical Trials

10,552 Total Patients Enrolled

National Institutes of Health (NIH)NIH

2,693 Previous Clinical Trials

6,951,459 Total Patients Enrolled

National Institute of Mental Health (NIMH)NIH

2,781 Previous Clinical Trials

2,674,845 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is it possible to participate in this research investigation?

"The criteria for joining this clinical trial necessitates that potential participants have received a placebo and are between 18 to 55 years old. The requirement is approximately 185 persons in total."

Answered by AI

Does the age criterion for this experiment permit individuals under 65 years old to participate?

"In adherence with the predetermined parameters of this research project, no participants below 18 years old can be included and all must be under 55."

Answered by AI

Are any persons eligible to participate in the current trial?

"According to the information provided on clinicaltrials.gov, recruitment for this trial has been terminated; it was initially listed in late 2020 and last edited in July of 2022. Nonetheless, there are presently 12 other trials that require participants."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Effects of Expectations on Negative Affect, Perceived Cognitive Effort, and Pain

Tor Wager 2020. "Effects of Expectations on Negative Affect, Perceived Cognitive Effort, and Pain". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT05425563.