Pre-Workout Supplement for Exercise Performance
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial explores whether a new pre-workout supplement can boost exercise performance in healthy adults. Researchers aim to determine if the supplement enhances endurance and strength, reduces exercise fatigue, and influences mood and energy levels. Participants will use both the proprietary pre-workout supplement and a placebo, reporting their experiences during and after exercise. Ideal candidates exercise regularly but not professionally and do not currently use other performance-enhancing supplements. As an unphased trial, this study provides a unique opportunity to contribute to the understanding of exercise supplements and their potential benefits.
Do I have to stop taking my current medications for the trial?
You may need to stop taking certain supplements like creatine, rhodiola, L-Theanine, glycerol, and other performance enhancers for at least two weeks before and during the study. Prescription medications that affect exercise adaptation may also need to be stopped. It's best to discuss your specific medications with the study team.
Is there any evidence suggesting that this trial's treatments are likely to be safe?
Research shows that pre-workout supplements can cause side effects, including stomach problems, changes in heart rhythm, and higher blood pressure. Some studies suggest that daily use might lead to heart issues or reduce effectiveness as the body becomes accustomed to them.
Limited evidence exists on how short-term use affects hormones or muscle damage from exercise. Many pre-workout supplements contain multiple ingredients, sometimes including substances banned in sports.
Overall, while pre-workout supplements are marketed to enhance exercise performance, potential risks should be considered. Monitoring the body's reactions and consulting a healthcare professional if concerns arise is advisable.12345Why are researchers excited about this trial?
Researchers are excited about the proprietary pre-workout supplement because it introduces a unique approach to enhancing exercise performance. Unlike other pre-workout options that often rely on stimulants like caffeine, this supplement uses a Liquid IV pre-workout powder designed to optimize hydration and nutrient delivery. This innovative delivery method could potentially improve endurance and recovery times, making it a promising alternative for athletes and fitness enthusiasts looking for a balanced performance boost without the jitters commonly associated with traditional pre-workouts.
What evidence suggests that this pre-workout supplement might be effective for improving exercise performance?
Research has shown that pre-workout supplements can greatly enhance exercise performance. In one study, participants who took these supplements demonstrated more power and endurance than those who received a placebo. Another study found that pre-workout supplements helped reduce tiredness and increase strength during exercise. Caffeine, a common ingredient in these supplements, boosts athletic performance and focus. In this trial, participants will receive either the proprietary pre-workout supplement or a control placebo. These findings suggest that the new pre-workout supplement being tested could effectively improve endurance, strength, and mood during workouts.678910
Who Is on the Research Team?
Eric Sikorski, PhD
Principal Investigator
Applied Science and Performance Institute
Are You a Good Fit for This Trial?
This trial is for healthy adults interested in improving their exercise performance. Participants should be looking to enhance muscle endurance, strength, energy levels, and cognition during workouts. Specific eligibility criteria are not provided but typically would exclude those with health conditions affecting physical activity.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants take the pre-workout supplement or placebo before exercise in two separate sessions and complete exercise tests
Follow-up
Participants are monitored for safety and effectiveness after treatment
What Are the Treatments Tested in This Trial?
Interventions
- Control placebo
- proprietary pre-workout supplement
Trial Overview
Researchers are testing a proprietary pre-workout supplement against a placebo to see if it improves exercise performance, reduces perceived exertion, and positively affects mood and energy. Participants will take the supplement or placebo before exercising in two separate sessions.
How Is the Trial Designed?
2
Treatment groups
Experimental Treatment
Placebo Group
Liquid IV pre-workout supplement powder
inactive/inert placebo mixture
Find a Clinic Near You
Who Is Running the Clinical Trial?
Applied Science & Performance Institute
Lead Sponsor
Citations
Pre-Workout Supplements and Their Effects on ...
Pre-workout supplements were associated with improved physical performance and possible cardiovascular changes, with these effects being ...
The effect of acute pre-workout supplementation on power ...
Ingestion of the pre-workout dietary supplement led to significant improvements in anaerobic peak and mean power values in comparison to the placebo and ...
Acute effects of a commercially-available pre-workout ...
Research on beta-alanine has shown that supplementation improves the rate of fatigue in sprinters [Citation10] and improves YoYo Intermittent ...
The Acute Effects of Liquid IV's Pre-Workout Supplement ...
The goal of this study is to learn if a new pre-workout supplement can improve exercise performance in healthy adults.
5.
uhhospitals.org
uhhospitals.org/blog/articles/2025/05/pre-workout-supplements-are-they-worth-takingPre-Workout Supplements: Are They Worth Taking?
“Caffeine is the most widely studied pre-workout ingredient and a proven enhancer of athletic performance, alertness and concentration,” says ...
Efficacy and safety of ingredients found in preworkout ...
Adverse effects reported in association with preworkout supplements include gastrointestinal symptoms, cardiac arrhythmia, blood pressure ...
Multi-ingredient pre-workout supplements, safety implications ...
Limited evidence exists regarding the effect of short-term MIPS consumption on hormones or markers of muscle damage caused by acute exercise.
8.
mcpress.mayoclinic.org
mcpress.mayoclinic.org/nutrition-fitness/preworkout-supplements-whats-safe-what-should-you-avoid/Preworkout supplements: What's safe? What should you ...
Marketed to boost performance during a workout. Intended to be ... For a performance benefit, consume nitrate 2 to 3 hours before exercise.
Is daily pre-workout (pre-exercise) supplement use safe?
Daily use of pre-workout supplements is generally not recommended due to potential cardiovascular risks, tolerance development to key ...
Full article: Multi-ingredient pre-workout supplements ...
As with any dietary supplement, the use of MIPS carries implications for the athlete, as many formulations may intentionally contain banned ...
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