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Beetroot juice for Peripheral Arterial Disease

N/A
Waitlist Available
Research Sponsored by University of Nebraska
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up maximum of 30 minutes each day for 2 days
Awards & highlights

Study Summary

This trial is designed to study the effects of dietary nitrate supplementation on peripheral artery disease.

Eligible Conditions
  • Peripheral Arterial Disease

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~maximum of 14 minutes each day for 2 days
This trial's timeline: 3 weeks for screening, Varies for treatment, and maximum of 14 minutes each day for 2 days for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Endothelial Function
Secondary outcome measures
Autonomic nervous system activity
Leg Blood Flow
Microvascular function
+3 more

Trial Design

2Treatment groups
Experimental Treatment
Group I: Placebo-Beetroot juiceExperimental Treatment1 Intervention
Subjects will be tested on two different days. The first day will be a placebo and the second day will be beetroot juice. Testing will take place approximately one hour after intake. There will be a 14 day washout period between testing days.
Group II: Beetroot juice-PlaceboExperimental Treatment1 Intervention
Subjects will be tested on two different days. The first day will be beetroot juice and the second day will be a placebo. Testing will take place approximately one hour after intake. There will be a 14 day washout period between testing days.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Beetroot juice
2022
Completed Phase 4
~620

Find a Location

Who is running the clinical trial?

University of NebraskaLead Sponsor
536 Previous Clinical Trials
1,143,912 Total Patients Enrolled
11 Trials studying Peripheral Arterial Disease
494 Patients Enrolled for Peripheral Arterial Disease

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Am I eligible to participate in this scientific experiment?

"Those with peripheral arterial disease aged between 50 and 85 are suitable for this medical trial, which is currently enrolling 10 individuals."

Answered by AI

Is this clinical trial still open to potential participants?

"Clinicaltrials.gov attests that this medical study—which was inaugurated on September 5th, 2018 and updated as recently as June 9th 2022—is not currently taking in participants; however, there are 216 other trials actively enrolling at the moment."

Answered by AI

What age restrictions are in place for prospective participants of this research?

"As indicated by the requirements for enrollment, participants must be between 50 and 85 years old."

Answered by AI
Recent research and studies
Journal of Applied PhysiologyJournal
Inorganic Nitrate Supplementation Improves Muscle Oxygenation, O<sub>2</sub>uptake Kinetics, and Exercise Tolerance at High but Not Low Pedal Rates
Bailey, Stephen J., Richard L. Varnham, Fred J. DiMenna, Brynmor C. Breese, Lee J. Wylie, and Andrew M. Jones. 2015. “Inorganic Nitrate Supplementation Improves Muscle Oxygenation, O2uptake Kinetics, and Exercise Tolerance at High but Not Low Pedal Rates”. Journal of Applied Physiology. American Physiological Society. doi:10.1152/japplphysiol.01141.2014.
Journal of Applied PhysiologyJournal
Dietary Nitrate Supplementation Reduces the O<sub>2</sub>cost of Walking and Running: A Placebo-controlled Study
Lansley, Katherine E., Paul G. Winyard, Jonathan Fulford, Anni Vanhatalo, Stephen J. Bailey, Jamie R. Blackwell, Fred J. DiMenna, Mark Gilchrist, Nigel Benjamin, and Andrew M. Jones. 2011. “Dietary Nitrate Supplementation Reduces the O2cost of Walking and Running: A Placebo-controlled Study”. Journal of Applied Physiology. American Physiological Society. doi:10.1152/japplphysiol.01070.2010.
Acta PhysiologicaJournal
Effects of Dietary Nitrate on Oxygen Cost During Exercise
Larsen, F. J., E. Weitzberg, J. O. Lundberg, and B. Ekblom. 2007. “Effects of Dietary Nitrate on Oxygen Cost During Exercise”. Acta Physiologica. Wiley. doi:10.1111/j.1748-1716.2007.01713.x.
HypertensionJournal
Acute Blood Pressure Lowering, Vasoprotective, and Antiplatelet Properties of Dietary Nitrate via Bioconversion to Nitrite
Webb, Andrew J., Nakul Patel, Stavros Loukogeorgakis, Mike Okorie, Zainab Aboud, Shivani Misra, Rahim Rashid, et al.. 2008. “Acute Blood Pressure Lowering, Vasoprotective, and Antiplatelet Properties of Dietary Nitrate via Bioconversion to Nitrite”. Hypertension. Ovid Technologies (Wolters Kluwer Health). doi:10.1161/hypertensionaha.107.103523.
~2 spots leftby Apr 2025
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