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Contrast Agent

Peripheral Artery Disease for Peripheral Arterial Disease

N/A
Recruiting
Research Sponsored by Oregon Health and Science University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 60 min post-therapeutic ultrasound cavitation
Awards & highlights

Study Summary

This trial will measure how much leg perfusion is increased by using ultrasound with microbubble contrast agents, which is an FDA-approved technique.

Eligible Conditions
  • Peripheral Arterial Disease

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~60 min post-therapeutic ultrasound cavitation
This trial's timeline: 3 weeks for screening, Varies for treatment, and 60 min post-therapeutic ultrasound cavitation for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Change in blood flow at 10 min
Change in blood flow at 60 min

Trial Design

2Treatment groups
Experimental Treatment
Group I: Peripheral Artery DiseaseExperimental Treatment1 Intervention
Low-power contrast ultrasound perfusion imaging and measurement of ABI and TBI will be performed before and after a 15 min high-power ultrasound cavitation therapy with intermittent ultrasound and intravenous infusion of microbubbles.
Group II: Healthy subjectsExperimental Treatment1 Intervention
Low-power contrast ultrasound perfusion imaging and measurement of ABI and TBI will be performed before and after a 15 min high-power ultrasound cavitation therapy with intermittent ultrasound and intravenous infusion of microbubbles.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Ultrasound
2013
Completed Phase 1
~1950

Find a Location

Who is running the clinical trial?

Oregon Health and Science UniversityLead Sponsor
973 Previous Clinical Trials
7,385,782 Total Patients Enrolled
4 Trials studying Peripheral Arterial Disease
919 Patients Enrolled for Peripheral Arterial Disease

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
clinicaltrials.govStudy
Augmentation of Limb Perfusion With Contrast Ultrasound
Jonathan R. Lindner, MD 2018. "Augmentation of Limb Perfusion With Contrast Ultrasound". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT03195556.
~4 spots leftby Apr 2025
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