← Back to Search

Polyol

Xylitol gum for Tooth Decay (PPaX Trial)

Q: Does this experiment accept participants aged 80 and above?

This clinical trial is available to patients between 18 and 64 years old. Additionally, there are 241 trials specifically for minors and 138 studies targeting seniors.

Q: Is the recruitment of participants for this trial still taking place?

The clinicaltrials.gov website indicates that this particular study is not actively enrolling patients; the investigation was originally made available on May 1st 2015 and last updated January 12th 2021. However, there are a total of 402 other trials currently open to participants.

Q: Am I a candidate to participate in this research?

This clinical trial is seeking 9365 participants aged 18 to 64 who have experienced premature births. To be eligible, individuals must fulfill the following conditions: having been enrolled in <a href="https://www.withpower.com/clinical-trials/pregnancy">pregnancy</a> prior to 20 weeks gestation according to best obstetrical estimate or postpartum with an expected next pregnancy within 18 months or preconception expecting a baby within that timeframe; cognitively aware and able to consent for the study as well as willing to participate in it and undergo at least two periodontal exams; and finally, committed on residing in the region for a whole year while chewing 1 piece of xylitol gum after morning and evening meals (if assigned to intervention sites

N/A

Waitlist Available

Led By Kjersti Aagaard, M.D.

Research Sponsored by Baylor College of Medicine

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be between 18 and 65 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up during pregnancy, up to 2 dental visits performed during pregnancy (approximately 37-40 weeks if term) to evaluate dental outcomes

Awards & highlights

PPaX Trial Summary

This trial will test if chewing gum can help prevent preterm birth and improve oral health.

Eligible Conditions

Tooth Decay
Gum Disease
Premature Birth

PPaX Trial Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ during pregnancy, up to 2 dental visits performed during pregnancy (approximately 37-40 weeks if term) to evaluate dental outcomes

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~during pregnancy, up to 2 dental visits performed during pregnancy (approximately 37-40 weeks if term) to evaluate dental outcomes

This trial's timeline: 3 weeks for screening, Varies for treatment, and during pregnancy, up to 2 dental visits performed during pregnancy (approximately 37-40 weeks if term) to evaluate dental outcomes for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Number of Infants <2500 Grams

Rate of Preterm Birth

Secondary outcome measures

Number of Infants With Adverse Neonatal Composite Morbidity and Mortality

Number of Participants With Dental Caries

Number of Participants With Periodontal Disease

PPaX Trial Design

2Treatment groups

Experimental Treatment

Active Control

Group I: XylitolExperimental Treatment1 Intervention

Cluster of sites receiving xylitol gum.

Group II: ControlActive Control1 Intervention

Cluster of sites not receiving xylitol gum. This is a cluster randomized trial, whereby 4 sites will not receive the intervention of xylitol gum in the prepregnancy and early pregnancy interval.

Treatment

First Studied

Drug Approval Stage

How many patients have taken this drug

Xylitol gum

2015

N/A

~10070

Do I qualify?Apply below to find out

Find a Location

Who is running the clinical trial?

Baylor College of MedicineLead Sponsor

1,000 Previous Clinical Trials

5,991,861 Total Patients Enrolled

Kjersti Aagaard, M.D.Principal InvestigatorBaylor College of Medicine

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Does this experiment accept participants aged 80 and above?

"This clinical trial is available to patients between 18 and 64 years old. Additionally, there are 241 trials specifically for minors and 138 studies targeting seniors."

Answered by AI

Is the recruitment of participants for this trial still taking place?

"The clinicaltrials.gov website indicates that this particular study is not actively enrolling patients; the investigation was originally made available on May 1st 2015 and last updated January 12th 2021. However, there are a total of 402 other trials currently open to participants."

Answered by AI

Am I a candidate to participate in this research?

"This clinical trial is seeking 9365 participants aged 18 to 64 who have experienced premature births. To be eligible, individuals must fulfill the following conditions: having been enrolled in pregnancy prior to 20 weeks gestation according to best obstetrical estimate or postpartum with an expected next pregnancy within 18 months or preconception expecting a baby within that timeframe; cognitively aware and able to consent for the study as well as willing to participate in it and undergo at least two periodontal exams; and finally, committed on residing in the region for a whole year while chewing 1 piece of xylitol gum after morning and evening meals (if assigned to intervention sites"

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Saving Lives at Birth: Primary Prevention of Periodontal Disease in Relation to Preterm Birth in Malawi

Kjersti Aagaard 2015. "Saving Lives at Birth: Primary Prevention of Periodontal Disease in Relation to Preterm Birth in Malawi". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT02333227.