Cognitive Training for Parkinson's Disease

Overseen By Sule Tinaz, MD, PhD

Age: 18+

Sex: Any

Trial Phase: Academic

Sponsor: Yale University

Must be taking: Dopaminergic medications

Disqualifiers: Non-English, Pregnancy, Alcohol, Neurological disorders, others

No Placebo Group All trial participants will receive the active study treatment (no placebo)

Compensation: Varies

Number of Visits: Unknown

Duration: 12 weeks

31 Participants Needed

What You Need to Know Before You Apply

What is the purpose of this trial?

The purpose of this research study is to determine whether cognitive training will improve cognitive and brain functions in people with Parkinson's Disease (PD) during activities of daily living using cognitive evaluations and magnetic resonance imaging (MRI).

Who Is on the Research Team?

Sule Tinaz, MD, PhD

Principal Investigator

Yale University

Are You a Good Fit for This Trial?

This trial is for people over 40 with Parkinson's Disease who are on stable medication. Participants must speak English, not be pregnant or breastfeeding, have no excessive alcohol use, and no metal implants that affect MRI scans. They should be able to lie flat for an hour and not have severe cognitive impairments or other neurological disorders.

Inclusion Criteria

I am 40 years old or older.

I will be on a stable medication for dopamine regulation during the study.

I have been diagnosed with Parkinson's disease.

Exclusion Criteria

My Parkinson's disease is advanced; I can stand and walk but need help.

You have been diagnosed with dementia, and your Montreal Cognitive Assessment score is less than 21 out of 30.

I do not have severe tremors or uncontrollable movements that could affect imaging tests.

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Treatment

Participants undergo cognitive training to improve cognitive and brain functions

12 weeks

Regular sessions (frequency not specified)

Follow-up

Participants are monitored for changes in cognitive function and brain connectivity

4 weeks

What Are the Treatments Tested in This Trial?

Interventions

• Mental Imagery Training
• Psychoeducation

Trial Overview The study tests if mental imagery training and psychoeducation can improve thinking skills and brain function in daily activities for those with Parkinson's. It involves cognitive assessments and MRIs to measure the effects of the interventions.

How Is the Trial Designed?

Group I: Mental Imagery Experimental Treatment 1 Intervention

Group II: Psychoeducation Active Control 1 Intervention

Who Is Running the Clinical Trial?

Yale University

Lead Sponsor

Trials

1,963

Recruited

3,046,000+

National Institute of Neurological Disorders and Stroke (NINDS)

Collaborator

Trials

1,403

Recruited

655,000+