cognitive training for Parkinson Disease

Phase-Based Estimates
1
Effectiveness
1
Safety
Edward Hines Jr. VA Hospital, Hines, IL, Hines, IL
Parkinson Disease+3 More
cognitive training - Behavioral
Eligibility
18+
All Sexes
Eligible conditions
Parkinson Disease

Study Summary

This study is evaluating whether a computerized cognitive training program can help improve memory and thinking skills.

See full description

Eligible Conditions

  • Parkinson Disease
  • Cognitive Decline
  • Parkinson's Disease (PD)
  • Mild Cognitive Impairment (MCI)
  • Cognitive Dysfunction

Treatment Effectiveness

Study Objectives

This trial is evaluating whether cognitive training will improve 1 primary outcome in patients with Parkinson Disease. Measurement will happen over the course of week 0 (before intervention begins), 8 weeks, 12 weeks.

Week 12
change in NIH sponsored Executive Abilities: Measures and Instruments for neurobehavioral evaluation and re-search (NIH-EXAMINER) executive composite score

Trial Safety

Trial Design

3 Treatment Groups

cognitive and memory strategy control training
cognitive and memory strategy training

This trial requires 45 total participants across 3 different treatment groups

This trial involves 3 different treatments. Cognitive Training is the primary treatment being studied. Participants will all receive the same treatment. There is no placebo group. The treatments being tested are not being studied for commercial purposes.

cognitive and memory strategy trainingThe cognitive training will include 4 sessions/week for 8 weeks. Each session will take 30min. Total hours of training is 16 hours. For memory strategy training, strategies will be performed daily; this will take only a few minutes a day to accomplish.
cognitive and memory strategy control trainingThe cognitive training will include 4 sessions/week for 8 weeks. Each session will take 30min. Total hours of training is 16 hours. For the active control of memory strategy training, strategies will be performed daily; this will take only a few minutes a day to accomplish.
active control for cognitive and memory strategy trainingThe cognitive training will include 4 sessions/week for 8 weeks. Each session will take 30min. Total hours of training is 16 hours. For the active control of memory strategy training, strategies will be performed daily; this will take only a few minutes a day to accomplish.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
cognitive training
2009
N/A
~410

Trial Logistics

Trial Timeline

Approximate Timeline
Screening: ~3 weeks
Treatment: Varies
Reporting: week 0 (before intervention begins), 8 weeks, 12 weeks
This trial has the following approximate timeline: 3 weeks for initial screening, variable treatment timelines, and roughly week 0 (before intervention begins), 8 weeks, 12 weeks for reporting.

Closest Location

Edward Hines Jr. VA Hospital, Hines, IL - Hines, IL

Eligibility Criteria

This trial is for patients born any sex aged 18 and older. There are 6 eligibility criteria to participate in this trial as listed below.

Mark “yes” if the following statements are true for you:
50 years or older
Speak and read English
Veterans who seek services at Hines VA Hospital
Diagnosis of PD as determined by the UK Parkinson's Disease Society Brain Bank Diagnostic Criteria
Meet criteria for having mild cognitive impairment
Receiving stable (i.e., no changes in medication and medication dose) medication and who are expected to remain on stable medication for the duration of the RCT

Patient Q&A Section

Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Can parkinson disease be cured?

Add answer

It is not possible to cure PD, but new medications, medications for symptom control, and dopaminergic/cholinergic agonist therapy have all shown promise in improving PD symptoms.

Unverified Answer

What causes parkinson disease?

Add answer

This is a newly identified cause of PD, which may explain in part why PD tends to affect adults at an estimated age of sixty-nine years at the time of diagnosis.

Unverified Answer

How many people get parkinson disease a year in the United States?

Add answer

About 15,000 new cases were diagnosed with Parkinson's or Dementia in 2003 in the United States, while 10,000 deaths were registered. This corresponds to 1.4 new cases in every 1,000 persons per year. The number of new cases of Parkinson's has steadily diminished for at least the last 50 years. Over the same period, annual rates of mortality have decreased only slightly, from 7.5 in 1966 to 6.3 in 2003. Based on current estimates, the number of people with Parkinson's or dementia who will die during the year will be slightly less than 7,500 in 2003.

Unverified Answer

What are the signs of parkinson disease?

Add answer

parkinsonian signs may arise from an underlying medical condition such as lung cancer and also from a subcortical stroke. parkinsonism is typically more obvious in one half of patients than the other half.

Unverified Answer

What is parkinson disease?

Add answer

PD is a disease with onset of symptoms in adulthood characterized by a loss of motor function causing trembling, muscle stiffness, and trembling or shaking while undertaking movements. This can eventually lead to problems getting up and falling down. There is not much that can be done in terms of rehabilitation for PD.\n

Unverified Answer

What are common treatments for parkinson disease?

Add answer

Most treatments include medications, surgical or non-surgical interventions, and rehabilitation. This information will help clinicians treat patients who have symptoms of Parkinson's disease, as most of the therapies mentioned for Parkinson's disease are used for symptoms of the disease as well.

Unverified Answer

What is the average age someone gets parkinson disease?

Add answer

Although the lifetime incidence of parkinsonism in the United States is not clear, we can extrapolate that in 2001 the average age of onset was 69.1 (65.4 ± 8.5 years, for early onset; 73.6 ± 8.1 years, for late onset). The gender difference in onset may be due to gender differences in environmental risks and/or gender-related genetic polymorphisms. The mean age at diagnosis is approximately 17 years earlier in African-American than Caucasians.

Unverified Answer

Have there been other clinical trials involving cognitive training?

Add answer

Currently, there is no good evidence that cognitive training alters the disease course or any of the tested outcome measures in PD. Results from a recent clinical trial suggest that the current paradigm in which the effects of cognitive training are tested for a specific subset of deficits and are not generalised to all cognitive domains may be premature.

Unverified Answer

Does parkinson disease run in families?

Add answer

We found no evidence of familial clustering of the diagnosis of PD. However, the association between PD and a family history was statistically significant but of small magnitude and thus may be attributed to chance.

Unverified Answer

Who should consider clinical trials for parkinson disease?

Add answer

Clinical trials have been conducted in the past and the use of these studies have improved outcomes for patients with PD at all stages of disease progression. They will help us explore better ways of treating this disease and may help us develop new drugs for better outcomes in the future.

Unverified Answer

Is cognitive training safe for people?

Add answer

The findings do not support the hypothesis that cognitive training is not safe. Results from a recent paper do not refute the possibility that for people experiencing cognitive difficulties the gains from cognitive training are not large enough to justify the potential risks.

Unverified Answer

What is the primary cause of parkinson disease?

Add answer

The major causal factors identified from patients' perceptions are: environmental factors (e.g., sunlight), genetic factors (e.g., family history of Parkinson Disease), and traumatic brain injury. Furthermore, the patients most concerned with environmental factors were those who reported having had exposure to industrial chemicals, pesticides, traffic accidents and those who reported having had chronic infections (bacterial or viral). Most who reported a family history of Parkinson Disease were concerned with having inherited their condition. No specific types of environmental exposure were identified as a primary cause of Parkinson Disease.

Unverified Answer
See if you qualify for this trial
Get access to this novel treatment for Parkinson Disease by sharing your contact details with the study coordinator.