ZEST-E Exercise for Parkinson's Disease
(ZEST-E Trial)
What You Need to Know Before You Apply
What is the purpose of this trial?
This study will evaluate exercise delivered through the Zesty Exercise System for Therapeutic Engagement (ZEST-E) for people with Parkinson's disease when sessions are monitored either in person or remotely. Participants will complete robot-guided exercise three times per week for three weeks. The study will assess feasibility, retention, safety, acceptability, and tolerability of remotely monitored ZEST-E and will measure changes in functional performance using the Standing Forward Reach test and the 30-Second Chair Stand test. These outcomes reflect range of motion and lower-body strength targeted by the exercise program.
Who Is on the Research Team?
Madeleine Hackney, PhD
Principal Investigator
Emory University
Are You a Good Fit for This Trial?
This trial is for older adults with mild to moderate Parkinson's Disease (PD). Participants will engage in a robot-assisted exercise program called ZEST-E, which they'll do three times a week for three weeks. The exercises can be monitored either in person or remotely.Inclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants complete robot-guided exercise sessions three times per week for three weeks using the Zesty Exercise System for Therapeutic Engagement (ZEST-E), monitored either in person or remotely.
Follow-up
Participants are monitored for safety and effectiveness after treatment, with assessments of functional performance using the Standing Forward Reach test and the 30-Second Chair Stand test.
What Are the Treatments Tested in This Trial?
Interventions
- ZEST-E Robot-Assisted Exercise Program
Trial Overview
The study tests the Zesty Exercise System for Therapeutic Engagement (ZEST-E) on its feasibility, retention, safety, acceptability, and tolerability when monitoring PD patients remotely. It also measures improvements in functional performance like range of motion and lower-body strength.
How Is the Trial Designed?
2
Treatment groups
Experimental Treatment
Participants complete ZEST-E exercise sessions while the researcher or physical therapist monitors the session remotely via camera from outside the room. A trained caregiver is present in the room to provide safety oversight and to activate the robot's run-stop button if needed. Participants follow the same progression from seated to standing exercises as in the in-person arm, contingent on completion of the safety tutorial and demonstration of safe technique.
Participants complete ZEST-E exercise sessions with a researcher or physical therapist present in the same room to provide safety oversight. All participants begin with seated exercises in week 1 and may progress to standing exercises in weeks 2 and 3 after completing a safety tutorial and demonstrating understanding of standing-exercise precautions. The researcher monitors the robot, provides instructions, and may stop the robot at any time using the run-stop button if needed.
Find a Clinic Near You
Who Is Running the Clinical Trial?
Emory University
Lead Sponsor
Georgia Clinical & Translational Science Alliance
Collaborator
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