30 Participants Needed

Exercise for Parkinson's Disease

Age: 18+
Sex: Any
Trial Phase: Academic
Sponsor: Sule Tinaz
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

Trial Summary

Will I have to stop taking my current medications?

The trial information does not specify whether you need to stop taking your current medications.

What data supports the effectiveness of the treatment High-intensity Interval Training for Parkinson's Disease?

Research shows that high-intensity interval training (HIIT) can be safe and beneficial for people with Parkinson's Disease, potentially improving symptoms like balance and muscle strength. Similar intensive exercises, like resistance and endurance training, have shown positive effects on functional outcomes and quality of life in Parkinson's patients.12345

Is high-intensity exercise safe for people with Parkinson's disease?

Research shows that high-intensity exercise, including resistance and endurance training, is generally safe for people with Parkinson's disease and does not worsen symptoms. It may also improve balance, muscle strength, and quality of life.14678

How does high-intensity interval training differ from other treatments for Parkinson's disease?

High-intensity interval training (HIIT) is unique for Parkinson's disease as it may promote neuroplasticity (the brain's ability to reorganize itself) and potentially modify the disease, unlike standard treatments that are mainly symptomatic. HIIT involves short bursts of intense exercise followed by rest, which is different from continuous exercise routines.1491011

What is the purpose of this trial?

This pilot study will evaluate the short-term (3 months) and long-term (6 months) effectiveness of a high-intensity interval training (HIIT) program in improving cognitive function and self-efficacy in individuals with PD.

Eligibility Criteria

This trial is for individuals over 40 with Parkinson's Disease who are willing to participate in high-intensity exercise classes. It's not suitable for those already highly active, non-English speakers, or people with certain neuropsychiatric disorders or advanced stages of Parkinson's.

Inclusion Criteria

I am 40 years old or older.
I have been diagnosed with Parkinson's disease.
I am willing and able to do high-intensity interval training classes.

Exclusion Criteria

High levels of exercise at baseline (exercising at high intensity at least 3 times per week or moderate intensity at least 5 times per week)
Non-English speaking
I have Parkinson's with depression and anxiety but no other brain-related conditions.
See 1 more

Timeline

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Treatment

Participants in the HIIT group will attend 3 exercise classes per week for 3 months, while the control group will continue their standard care and usual physical activities

3 months
3 visits per week (in-person) for HIIT group

Follow-up

Participants are monitored for cognitive function and quality of life improvements at 3 and 6 months

3 months

Long-term Follow-up

Long-term effectiveness of HIIT on cognitive function and quality of life is evaluated

6 months

Treatment Details

Interventions

  • High-intensity Interval Training
Trial Overview The study tests the impact of a high-intensity interval training (HIIT) program on cognitive function and self-efficacy in Parkinson's patients over short-term (3 months) and long-term (6 months) periods.
Participant Groups
2Treatment groups
Experimental Treatment
Active Control
Group I: High-intensity interval trainingExperimental Treatment1 Intervention
Participants in the HIIT group will be expected to attend 3 exercise classes per week for 3 months
Group II: ControlActive Control1 Intervention
Participants in the control group will continue their standard care and usual physical activities

Find a Clinic Near You

Who Is Running the Clinical Trial?

Sule Tinaz

Lead Sponsor

Trials
1
Recruited
30+

Findings from Research

High-intensity interval training (HIIT) has been shown to significantly improve disease severity and quality of life in individuals with Parkinson's disease, based on a systematic review of 15 randomized clinical trials involving 654 participants.
While HIIT demonstrated benefits in motor function and functional mobility compared to control groups, the evidence comparing HIIT to moderate intensity exercise remains limited and shows variability among studies.
Feasibility and effect of high-intensity training on the progression of motor symptoms in adult individuals with Parkinson's disease: A systematic review and meta-analysis.Sena, IG., Costa, AVD., Santos, IKD., et al.[2023]
A survey of 64 Parkinson's Disease patients revealed that 67% exercised at least twice a week, with walking being the most common form of exercise, and 97% reported improvements in their symptoms due to exercise.
Patients who exercised in groups experienced greater symptomatic improvements compared to those who exercised alone, highlighting the potential added benefits of social interaction and cognitive engagement in group activities like dance therapy.
Self-Reported Exercise Trends in Parkinson's Disease Patients.Raje, P., Ning, S., Branson, C., et al.[2019]
Resistance training (RT) and endurance training (ET) are safe and feasible exercise modalities for people with Parkinson's disease, showing significant benefits in muscle strength, functional capacity, and quality of life based on a review of 33 new randomized controlled trials.
RT demonstrated a strong positive impact on muscle strength (SMD = 0.83) and functional capacity, while ET improved cardiorespiratory fitness (SMD = 0.27) and also showed potential benefits for functional outcomes, indicating that both types of exercise can be effective adjunct therapies for managing Parkinson's disease.
Parkinson's disease and intensive exercise therapy - An updated systematic review and meta-analysis.Gamborg, M., Hvid, LG., Dalgas, U., et al.[2022]

References

Feasibility and effect of high-intensity training on the progression of motor symptoms in adult individuals with Parkinson's disease: A systematic review and meta-analysis. [2023]
The effects of balance training and high-intensity resistance training on persons with idiopathic Parkinson's disease. [2022]
Self-Reported Exercise Trends in Parkinson's Disease Patients. [2019]
Parkinson's disease and intensive exercise therapy - An updated systematic review and meta-analysis. [2022]
Phase II randomised controlled trial of a 6-month self-managed community exercise programme for people with Parkinson's disease. [2021]
Study in Parkinson disease of exercise (SPARX): translating high-intensity exercise from animals to humans. [2021]
Sprint exercise for subjects with mild-to-moderate Parkinson's disease: Feasibility and biomechanical outputs. [2021]
The meaning of regular participation in vigorous-intensity exercise among men with Parkinson's disease. [2022]
A High-Intensity Exercise Boot Camp for Persons With Parkinson Disease: A Phase II, Pragmatic, Randomized Clinical Trial of Feasibility, Safety, Signal of Efficacy, and Disease Mechanisms. [2022]
High-Intensity Interval Cycle Ergometer Training in Parkinson's Disease: Protocol for Identifying Individual Response Patterns Using a Single-Subject Research Design. [2020]
11.United Statespubmed.ncbi.nlm.nih.gov
FIGHT-PD: A feasibility study of periodized boxing training for Parkinson disease. [2023]
Unbiased ResultsWe believe in providing patients with all the options.
Your Data Stays Your DataWe only share your information with the clinical trials you're trying to access.
Verified Trials OnlyAll of our trials are run by licensed doctors, researchers, and healthcare companies.
Back to top
Terms of Service·Privacy Policy·Cookies·Security