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Behavioural Intervention

Instability training group (IRT) for Exercise

N/A
Waitlist Available
Led By Alisha Mistry
Research Sponsored by Sun Life Financial Movement Disorders Research and Rehabilitation Centre
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up change from baseline motor and non-motor functions tested after 8 weeks of intervention (post-test measured on consecutive week after last week of intervention)
Awards & highlights

Study Summary

This study will be looking at the effects that instability resistance training and aerobic training, individually, have on the improvement of various motor and cognitive impairments present in individuals with Parkinson' disease. There will be 25-30 participants in this study (all of whom have Parkinson's disease). Once passing the eligibility criteria, participants will complete as series of baseline/pre-tests and then be randomly assigned to either the aerobic training group or the instability training group, where they will participate in every training session that occurs in the next 8 consecutive weeks. There will be 3 training sessions a week occurring on non-consecutive days (ex. Monday, Wednesday, Friday) for both training groups (3 aerobic training sessions, 3 instability resistance training sessions). Once the 8 week training intervention has been completed, a series of post-tests will occur exactly once week after (same tests used as in the pre-tests)

Eligible Conditions
  • Exercise
  • Parkinson's Disease

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~change from baseline executive functions tested after 8 weeks of intervention (post-test measured on consecutive week after last week of intervention)
This trial's timeline: 3 weeks for screening, Varies for treatment, and change from baseline executive functions tested after 8 weeks of intervention (post-test measured on consecutive week after last week of intervention) for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
assessing comprehensive motor and non-motor symptoms
executive function (attention, working memory and recall verbal memory)
executive function (memory, language and concentration)
+5 more

Trial Design

2Treatment groups
Experimental Treatment
Group I: Instability training group (IRT)Experimental Treatment1 Intervention
Each IRT sessions are to last one hour, with time being allocated to a 10 minute warm up, consisting of static stretches, a 5 minute cool down, consisting of dynamic stretches, and a series of IRT exercises performed in a circuit setting over the duration of 40 minutes. In the sessions, five resistance exercises will be performed. A linear periodization will occur, in which the training load will progress from high-volume low-intensity to low-volume high-intensity loads over the duration of eight weeks to maximize training adaptations. Additionally, there will be a progressive increase in load/resistance by 1-2 lbs and the degree of instability of each exercise during the course of the eight week program. Unstable devices will be changed from the least unstable to the most unstable device throughout the program, but only when participants showed a considerable decrease in body sway/movement and force production increased when performing exercises.
Group II: Aerobic training group (AET)Experimental Treatment1 Intervention
Each AET sessions are to last one hour, with 40 minutes being allocated to the aerobic exercise training component, 10 minutes allocated to warm-ups, 5 minutes allocated to cool-downs, and one 5 minute rest period between the 20 minutes spent on each machine (20 minutes of cycling, 5 minute rest, 20 minutes seated row). The AET program consists of 20 minutes of cycling on the stationary bicycle and 20 minutes of seated row on the kinesis Technogym machine. This is to be preceded by 10 minutes of static stretching during warm up, and 5 minutes of post-exercise recovery (dynamic stretches).

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Who is running the clinical trial?

Sun Life Financial Movement Disorders Research and Rehabilitation CentreLead Sponsor
9 Previous Clinical Trials
477 Total Patients Enrolled
Alisha MistryPrincipal InvestigatorMovement Disorder Research and Rehabilitation Center

Frequently Asked Questions

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~5 spots leftby Apr 2025