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Amygdala recording and stimulation using Neuropace RNS for Panic Disorder

N/A

Waitlist Available

Led By Mahendra Bhati, MD

Research Sponsored by Stanford University

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up 2 days

Awards & highlights

Study Summary

This trial will test the feasibility of a new procedure to study the human amygdala, as well as the effects of stimulation on fear and reward processing.

Eligible Conditions

Panic Disorder
Post-Traumatic Stress Disorder
Anxiety

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ 2 days

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~2 days

This trial's timeline: 3 weeks for screening, Varies for treatment, and 2 days for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

ECoG (ElectroCorticoGraphy) amplitude changes

Electrocorticogram

EEG(electroencephalography) amplitude changes

+1 more

Secondary outcome measures

Electrophysiological changes in EDA

Electrophysiological changes in EMG

Trial Design

1Treatment groups

Experimental Treatment

Group I: Neurophysiological recording and stimulation of amygdalaExperimental Treatment2 Interventions

Recording and stimulation of amygdala using Neuropace RNS devices at certain points through out the behavioral tasks.

Treatment

First Studied

Drug Approval Stage

How many patients have taken this drug

Behavioral tasks

2009

N/A

~1300

Amygdala recording and stimulation using Neuropace RNS

2019

N/A

~30

Do I qualify?Apply below to find out

Find a Location

Who is running the clinical trial?

National Institute of Mental Health (NIMH)NIH

2,786 Previous Clinical Trials

2,689,676 Total Patients Enrolled

29 Trials studying Panic Disorder

7,254 Patients Enrolled for Panic Disorder

Stanford UniversityLead Sponsor

2,395 Previous Clinical Trials

17,341,327 Total Patients Enrolled

1 Trials studying Panic Disorder

136 Patients Enrolled for Panic Disorder

Mahendra Bhati, MDPrincipal InvestigatorStanford University

1 Previous Clinical Trials

795 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is recruitment for this experiment currently underway?

"The clinicaltrial.gov website informs that this medical trial is no longer accepting candidates, having posted initially on April 24th 2019 and last modified September 20th 2021. Nevertheless, 359 other studies are actively seeking patients at present."

Answered by AI

Are individuals 55 years and older being enrolled in this experimental program?

"Candidates wishing to take part in this trial must fall within the 18-65 age bracket. For those younger than 18, there are 48 studies available and 261 for individuals over 65 years of age."

Answered by AI

Can I be part of this experiment?

"To be eligible for inclusion in this trial, participants must suffer from panic attacks and have an age between 18 to 65. There are 30 open slots available overall."

Answered by AI

Recent research and studies

Biological PsychiatryJournal

Deep Brain Stimulation of the Basolateral Amygdala for Treatment-refractory Posttraumatic Stress Disorder

Langevin, Jean-Philippe, Ralph J. Koek, Holly N. Schwartz, James W.Y. Chen, David L. Sultzer, Mark A. Mandelkern, Alexis D. Kulick, and Scott E. Krahl. 2016. “Deep Brain Stimulation of the Basolateral Amygdala for Treatment-refractory Posttraumatic Stress Disorder”. Biological Psychiatry. Elsevier BV. doi:10.1016/j.biopsych.2015.09.003.

American Journal of PsychiatryJournal

Functional Neuroimaging of Anxiety: A Meta-analysis of Emotional Processing in PTSD, Social Anxiety Disorder, and Specific Phobia

Etkin, Amit, M.D., Ph.D, and Tor D. Wager Ph.D.. 2007. “Functional Neuroimaging of Anxiety: A Meta-analysis of Emotional Processing in PTSD, Social Anxiety Disorder, and Specific Phobia”. American Journal of Psychiatry. American Psychiatric Association Publishing. doi:10.1176/appi.ajp.2007.07030504.

NeuropsychologiaJournal

Rapid Amygdala Gamma Oscillations in Response to Fearful Facial Expressions

Sato, Wataru, Takanori Kochiyama, Shota Uono, Kazumi Matsuda, Keiko Usui, Yushi Inoue, and Motomi Toichi. 2011. “Rapid Amygdala Gamma Oscillations in Response to Fearful Facial Expressions”. Neuropsychologia. Elsevier BV. doi:10.1016/j.neuropsychologia.2010.12.025.

Nature Reviews NeuroscienceJournal