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Use of different concentrations of oxygen during ERCP for Pancreatitis

N/A
Waitlist Available
Led By Moamen M. Gabr, MD, MSc
Research Sponsored by Moamen Gabr
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 2 months (90 minutes post-procedure to 2months follow-up)
Awards & highlights

Study Summary

Effects of High FIO2 on Post-ERCP Pancreatitis.

Eligible Conditions
  • Pancreatitis

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~2 months (90 minutes post-procedure to 2months follow-up)
This trial's timeline: 3 weeks for screening, Varies for treatment, and 2 months (90 minutes post-procedure to 2months follow-up) for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Endoscopic Retrograde Cholangiopancreatography

Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: Use of 80% oxygen(high oxygen fraction) during ERCPExperimental Treatment1 Intervention
Anesthetist will open the envelope of randomly assigned groups which will assign patients to 80% FIO2(supplemental perioperative high oxygen fraction). 80% FIO2 will be maintained during the ERCP procedure. Maintaining oxygen saturation of > 92% through administration of oxygen via nasal cannula, mask or ventilator will be per anesthetist discretion. Additional supplemental oxygen will be given to patients at any time, as necessary, to maintain oxygen saturation as measured by pulse oximeter > 92%.
Group II: Use of 30% oxygen(normal oxygen fraction) during ERCPActive Control1 Intervention
Anesthetist will open the envelope of randomly assigned groups which will assign patients to 30% FIO2 (normal oxygen fraction). 30% FIO2 will be maintained during the ERCP procedure. Maintaining oxygen saturation of > 92% through administration of oxygen via nasal cannula, mask or ventilator will be per anesthetist discretion. Additional supplemental oxygen will be given to patients at any time, as necessary, to maintain oxygen saturation as measured by pulse oximeter > 92%.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Use of different concentrations of oxygen during ERCP
2021
N/A
~30

Find a Location

Who is running the clinical trial?

Moamen GabrLead Sponsor
Syed Z. Ali, MDLead Sponsor
Moamen M. Gabr, MD, MScPrincipal InvestigatorAssistant Professor, Internal Medicine, Gastroenterology

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
American Journal of GastroenterologyJournal
Risk Factors for Post-ercp Pancreatitis in High- and Low-volume Centers and Among Expert and Non-expert Operators: A Prospective Multicenter Study
Testoni, Pier Alberto, Alberto Mariani, Antonella Giussani, Cristian Vailati, Enzo Masci, Giampiero Macarri, Luigi Ghezzo, et al.. 2010. “Risk Factors for Post-ercp Pancreatitis in High- and Low-volume Centers and Among Expert and Non-expert Operators: A Prospective Multicenter Study”. American Journal of Gastroenterology. Ovid Technologies (Wolters Kluwer Health). doi:10.1038/ajg.2010.136.
New England Journal of MedicineJournal
Complications of Endoscopic Biliary Sphincterotomy
Freeman, Martin L., Douglas B. Nelson, Stuart Sherman, Gregory B. Haber, Mary E. Herman, Paul J. Dorsher, Joseph P. Moore, et al.. 1996. “Complications of Endoscopic Biliary Sphincterotomy”. New England Journal of Medicine. Massachusetts Medical Society. doi:10.1056/nejm199609263351301.
American Journal of GastroenterologyJournal
Complications of Diagnostic and Therapeutic Ercp: A Prospective Multicenter Study
Masci, E, G Toti, A Mariani, S Curioni, A Lomazzi, M Dinelli, G Minoli, et al.. 2001. “Complications of Diagnostic and Therapeutic Ercp: A Prospective Multicenter Study”. American Journal of Gastroenterology. Ovid Technologies (Wolters Kluwer Health). doi:10.1111/j.1572-0241.2001.03594.x.
The American Journal of GastroenterologyJournal
Incidence Rates of Post-ercp Complications: A Systematic Survey of Prospective Studies
Andriulli, Angelo, Silvano Loperfido, Grazia Napolitano, Grazia Niro, Maria Rosa Valvano, Fulvio Spirito, Alberto Pilotto, and Rosario Forlano. 2007. “Incidence Rates of Post-ercp Complications: A Systematic Survey of Prospective Studies”. The American Journal of Gastroenterology. Ovid Technologies (Wolters Kluwer Health). doi:10.1111/j.1572-0241.2007.01279.x.
~6 spots leftby Apr 2025
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