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Radiation Therapy

SBRT for Pancreatic Cancer (SBRT Trial)

N/A

Waitlist Available

Led By James D Murphy, MD

Research Sponsored by University of California, San Diego

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up from date of randomization to observed dose limiting toxicity (dlt) in 20% of patients assessed up to 3 years

Awards & highlights

SBRT Trial Summary

This trial will find the highest dose of radiation that can be given in five treatments that is still safe for pancreatic cancer patients.

Eligible Conditions

Pancreatic Cancer

SBRT Trial Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ from date of randomization to observed dose limiting toxicity (dlt) in 20% of patients assessed up to 3 years

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~from date of randomization to observed dose limiting toxicity (dlt) in 20% of patients assessed up to 3 years

This trial's timeline: 3 weeks for screening, Varies for treatment, and from date of randomization to observed dose limiting toxicity (dlt) in 20% of patients assessed up to 3 years for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Maximum Tolerated Dose

Secondary outcome measures

Distant Metastatic Progression Rate

Local Tumor Progression

Overall Survival

Side effects data

From 2024 Phase 2 trial • 57 Patients • NCT03004183

21%

Fatigue

13%

Nausea

11%

Back pain

Shortness of Breath

Anemia

Abdominal pain

Diarrhea

Pneumonia

Kidney Injury and/or Infection

Dyspnea

Weight Loss

Malnutrition, Hypercalcemia and Weakness

Pneumothorax

Intractable pain, back pain, hip pain

Activated partial thromboplastin time prolonged

Pleural effusion

Atrial fibrillation with rapid ventricular response

Thrombocytopenia

Respiratory failure

Skin rash

colitis

100%

80%

60%

40%

20%

Study treatment Arm

Single Arm

SBRT Trial Design

5Treatment groups

Experimental Treatment

Group I: Cohort 5Experimental Treatment1 Intervention

SBRT 60 Gy in 5 fractions

Group II: Cohort 4Experimental Treatment1 Intervention

SBRT 55 Gy in 5 fractions

Group III: Cohort 3Experimental Treatment1 Intervention

SBRT 50 Gy in 5 fractions

Group IV: Cohort 2Experimental Treatment1 Intervention

SBRT 45 Gy in 5 fractions (starting dose level)

Group V: Cohort 1Experimental Treatment1 Intervention

SBRT 40 Gy in 5 fractions

Treatment

First Studied

Drug Approval Stage

How many patients have taken this drug

SBRT

2014

Completed Phase 2

~1060

Do I qualify?Apply below to find out

Find a Location

Who is running the clinical trial?

University of California, San DiegoLead Sponsor

1,120 Previous Clinical Trials

1,521,377 Total Patients Enrolled

James D Murphy, MDPrincipal InvestigatorUniversity of California, San Diego

Media Library

SBRT (Radiation Therapy) Clinical Trial Eligibility Overview. Trial Name: NCT02454140 — N/A

Pancreatic Cancer Research Study Groups: Cohort 5, Cohort 2, Cohort 4, Cohort 1, Cohort 3

Pancreatic Cancer Clinical Trial 2023: SBRT Highlights & Side Effects. Trial Name: NCT02454140 — N/A

SBRT (Radiation Therapy) 2023 Treatment Timeline for Medical Study. Trial Name: NCT02454140 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Can individuals join this research endeavor at the present time?

"The information on clinicaltrials.gov suggests that this particular trial is no longer actively recruiting. It was initially posted in June 2014, and the last update came through 18th May 2022. Although there are no current openings for participation on this study, 703 other trials currently have open opportunities to join them."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Stereotactic Body Radiotherapy Dose Escalation in Pancreatic Cancer

James D. Murphy, MD, MS 2014. "Stereotactic Body Radiotherapy Dose Escalation in Pancreatic Cancer". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT02454140.