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Nonsteroidal Anti-inflammatory Drug

Celecoxib for Postoperative Knee Pain

N/A
Waitlist Available
Led By Adam Zanbilowicz, BA DPM MS
Research Sponsored by Zanbilowicz, Adam, DPM MS
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Timeline
Screening 3 weeks
Treatment Varies
Follow Up up to 5 years
Awards & highlights

Study Summary

This trial seeks to determine if pre-operative anti-inflammatory therapy can help reduce postoperative pain in patients who have undergone knee arthroplasty surgery.

Who is the study for?
This trial is for healthy individuals scheduled for knee arthroplasty surgery. It's not suitable for those with heart disease, ulcers, bleeding disorders, liver disease with certain enzyme levels above normal, or impaired kidney function. Also excluded are patients on ACE inhibitors, diuretics, daily NSAIDs during the study period; pregnant women or those planning pregnancy soon; and anyone allergic to NSAIDs.Check my eligibility
What is being tested?
The study tests if taking Celecoxib (a painkiller that doesn't affect bleeding) for seven days before knee surgery can reduce postoperative pain by addressing inflammation. Participants will be randomly assigned to receive either Celecoxib or a placebo without knowing which one they're getting.See study design
What are the potential side effects?
While Celecoxib avoids issues with bleeding unlike other NSAIDs, potential side effects may include digestive problems like stomach upset or more rarely serious conditions such as heart problems and skin reactions.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~up to 5 years
This trial's timeline: 3 weeks for screening, Varies for treatment, and up to 5 years for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Compare total pain rating in group receiving 7day celecoxib against in 1 dose celecoxib
Secondary outcome measures
1. Comparison of pain rating VRS "When you woke up following surgery," and at 24 hours and 48 hours postoperatively in the two study groups
Comparison of patient reported maximum pain on VRS in the study groups.

Find a Location

Who is running the clinical trial?

Zanbilowicz, Adam, DPM MSLead Sponsor
Adam Zanbilowicz, BA DPM MSPrincipal InvestigatorVancouver Coastal Health

Media Library

Celecoxib (Nonsteroidal Anti-inflammatory Drug) Clinical Trial Eligibility Overview. Trial Name: NCT00533247 — N/A
Postoperative Pain Research Study Groups:
Postoperative Pain Clinical Trial 2023: Celecoxib Highlights & Side Effects. Trial Name: NCT00533247 — N/A
Celecoxib (Nonsteroidal Anti-inflammatory Drug) 2023 Treatment Timeline for Medical Study. Trial Name: NCT00533247 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
clinicaltrials.govStudy
Arthroplasty Inflammation Prophylaxis With Celecoxib
2024. "Arthroplasty Inflammation Prophylaxis With Celecoxib". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT00533247.
~133 spots leftby Apr 2025
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