Dexmedetomidine + Ketamine for Postoperative Pain
Trial Summary
Will I have to stop taking my current medications?
The trial requires that you stop taking certain medications, such as beta-blockers, pregabalin, gabapentin, amitryptillin, nortryptillin, and duloxetin, before participating.
What data supports the effectiveness of the drug combination of Dexmedetomidine and Ketamine for postoperative pain?
Is the combination of dexmedetomidine and ketamine generally safe for humans?
How does the drug combination of Dexmedetomidine and Ketamine differ from other pain management options?
The combination of Dexmedetomidine and Ketamine for postoperative pain is unique because it leverages the calming effects of Dexmedetomidine and the pain-relieving properties of Ketamine, potentially reducing the need for opioids and their associated side effects. This combination can enhance pain relief and extend the duration of analgesia compared to using either drug alone or standard pain management options.148910
What is the purpose of this trial?
Postoperative pain after VATS surgery is significant and associated with moderate to high post operative morphine requirements, which can cause opioid related side effects and delay postoperative recovery. To reduce this requirement, multimodal analgesia with non opioid medication such as dexmedetomidine and ketamine can be used. These drugs have demonstrated significant opioid-sparing properties after various types of surgeries. However, very little is known about their ability to do so in VATS surgery. Also, their relative opioid-sparing properties have not been compared, and it is not known whether their combined use can lead to an additional opioid-sparing effect. The primary goal of this study will be to determine the impact of a combined intra operative infusion of ketamine and dexmedetomidine on postoperative morphine requirements in patients undergoing elective VATS, compared to both these drugs infused separately.The hypothesis is that this combined infusion will lead to a 30% further reduction in morphine requirements, 24h after surgery, compared to both these drugs infused separately.
Research Team
Veronique Brulotte, MD
Principal Investigator
Ciusss de L'Est de l'Île de Montréal
Eligibility Criteria
This trial is for adults aged 18-80 undergoing elective lung surgery (VATS) who are generally healthy or have mild to moderate systemic disease. It's not for those planning to use regional anesthesia post-surgery, on certain pain medications like beta-blockers or chronic pain treatments, with allergies to the study drugs, pregnant, unable to consent, or facing language barriers.Inclusion Criteria
Exclusion Criteria
Timeline
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Intraoperative infusion of ketamine and dexmedetomidine to reduce postoperative morphine requirements
Postoperative Monitoring
Monitoring of postoperative morphine requirements and pain scores at rest and after coughing
Follow-up
Participants are monitored for persistent postoperative pain and other outcomes
Treatment Details
Interventions
- Dexmedetomidine and Ketamine
Find a Clinic Near You
Who Is Running the Clinical Trial?
Ciusss de L'Est de l'Île de Montréal
Lead Sponsor