Genicular Nerve Block for Knee Pain
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial tests a new method for managing knee pain using genicular nerve blocks. The aim is to determine if this treatment, which combines bupivacaine (a numbing agent) and corticosteroids (inflammation reducers), is more effective than standard pain relief methods. Participants will receive either the nerve block or standard pain care in an emergency setting. The trial seeks individuals with knee pain not caused by an injury, confirmed by an x-ray showing no major swelling or fractures. Ideal candidates experience moderate to severe knee pain that affects their daily activities. As an unphased trial, this study provides a unique opportunity to explore innovative pain management options.
Do I have to stop taking my current medications for the trial?
The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.
What prior data suggests that the genicular nerve block is safe for treating knee pain?
Research has shown that using a genicular nerve block (GNB) with bupivacaine and corticosteroids is generally safe for treating knee pain. Studies indicate that this treatment often provides significant pain relief for many people. For example, one study found that patients experienced noticeable pain reduction for up to six months.
The procedure is usually well-tolerated. A report found that GNB is safe for people with knee osteoarthritis, a common knee condition. Another study showed that this treatment offered more pain relief than a placebo.
Overall, while individual experiences may differ, research suggests that GNB with bupivacaine and corticosteroids is a safe and effective way to manage knee pain.12345Why are researchers excited about this trial?
Researchers are excited about the genicular nerve block with bupivacaine and corticosteroids for knee pain because it targets pain directly at the nerve level, potentially offering faster and more effective relief than standard oral medications like NSAIDs or opioids. Unlike traditional treatments that can take a systemic approach, this nerve block is locally administered, minimizing potential side effects associated with widespread painkillers. Furthermore, the combination of bupivacaine, a local anesthetic, and corticosteroids, which reduce inflammation, provides a dual-action approach that could offer longer-lasting pain relief.
What evidence suggests that the genicular nerve block might be an effective treatment for knee pain?
Research has shown that genicular nerve blocks (GNB) with bupivacaine and corticosteroids can significantly reduce knee pain. Many patients experience noticeable relief lasting for weeks. In this trial, one group of participants will receive the genicular nerve block for their knee pain. One study found that pain relief was much better compared to a placebo, with patients reporting a 2-point improvement on a 10-point pain scale. Another study demonstrated that adding a corticosteroid to the nerve block can extend the duration of pain relief. Overall, these findings suggest that GNB can effectively manage knee pain.13467
Who Is on the Research Team?
Michael M Shalaby, MD
Principal Investigator
University of Pennsylvania
Are You a Good Fit for This Trial?
This trial is for individuals who are experiencing knee pain without a major swelling in the knee, as shown by x-ray. Specific eligibility details aren't provided, but typically participants would need to meet certain health criteria and not have conditions that could interfere with the study.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive either a genicular nerve block or standard of care analgesia for knee pain in the emergency department
Follow-up
Participants are monitored for pain levels and other outcomes after treatment
What Are the Treatments Tested in This Trial?
Interventions
- Genicular Nerve Block with Bupivacaine and Corticosteroids
Find a Clinic Near You
Who Is Running the Clinical Trial?
University of Pennsylvania
Lead Sponsor