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Focused Ultrasound

Focused Ultrasound for Frailty (fUS-ARF Trial)

Q: Who is eligible to join this medical experiment?

This clinical trial seeks 50 frail individuals in the age bracket between 45 and 95 years old, with a lower eligibility threshold of 60. Qualifying patients must have been clinically appraised as exhibiting signs of frailty (outside of any concurrent condition) and be rated 3 to 7 on the CSHA Clinical Frailty Scale by their physician.

Q: Is the age range for this research limited to those over 25 years?

According to the trial's eligibility requirements, participants must lie within 45 and 95 years old. Additionally, there are 7 studies for minors under 18 and 371 clinical trials dedicated to patients aged 65 or above.

Q: Are there any vacancies remaining for this medical investigation?

According to the clinicaltrials.gov database, this medical study is not accepting patients presently. It was uploaded on September 1st 2023 and last revised on September 26th 2022. Although enrollment for this trial has been suspended, there are still 380 other trials open for recruitment of participants at present.

Phase < 1

Waitlist Available

Led By Sheldon Jordan, MD

Research Sponsored by Neurological Associates of West Los Angeles

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Age eligibility requirements fall in a range from 60 to 95 years of age

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up final evaluation (8 weeks from baseline)

Awards & highlights

fUS-ARF Trial Summary

This trial is testing whether transcranial ultrasound is safe and effective in treating age-related frailty.

Who is the study for?

This study is for people aged 60-95 showing signs of frailty but not from another condition, scoring between 3 and 7 on the Frailty Scale. They must have a brain MRI with hypothalamus volume measured. It's not for those who can't lie still, are pregnant or breastfeeding, have terminal illness, can't consent, or have scalp issues.Check my eligibility

What is being tested?

The trial tests transcranial ultrasound as a treatment for age-related frailty. This Phase I open label study aims to assess its tolerability over time and potential effectiveness in improving symptoms of frailty.See study design

What are the potential side effects?

Since this is an early-stage trial focusing on transcranial ultrasound therapy, specific side effects aren't listed but may include discomfort at the site of application or headache due to sound waves.

fUS-ARF Trial Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Select...

I am between 60 and 95 years old.

fUS-ARF Trial Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ final evaluation (8 weeks from baseline)

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~final evaluation (8 weeks from baseline)

This trial's timeline: 3 weeks for screening, Varies for treatment, and final evaluation (8 weeks from baseline) for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Clinical Frailty Scale (CFS)

Secondary outcome measures

Beck Anxiety Inventory (BAI)

Beck Depression Inventory (BDI-II)

Community Healthy Activities Model Program for Seniors (CHAMPS)

+5 more

fUS-ARF Trial Design

1Treatment groups

Experimental Treatment

Group I: ExperimentalExperimental Treatment1 Intervention

Participants will undergo ten to thirty minutes of transcranial ultrasound treatment. The sanitation device will be aimed at the hypothalamus. Targeting will include reference to scalp fiducials based on the obtained MRI; confirmation of target accuracy will either be obtained by Doppler waveform confirmation or optical tracking technology which co-registers patient neuroimaging with real space.

Treatment

First Studied

Drug Approval Stage

How many patients have taken this drug

Focused Ultrasound

2012

Completed Phase 2

~50

0 / 1Eligibility criteria met

Find a Location

Who is running the clinical trial?

Neurological Associates of West Los AngelesLead Sponsor

25 Previous Clinical Trials

3,910 Total Patients Enrolled

1 Trials studying Frailty

100 Patients Enrolled for Frailty

Sheldon Jordan, MDPrincipal InvestigatorNeurological Associates - The Interventional Group

12 Previous Clinical Trials

2,540 Total Patients Enrolled

Media Library

Transcranial Ultrasound (Focused Ultrasound) Clinical Trial Eligibility Overview. Trial Name: NCT04770350 — Phase < 1

Frailty Research Study Groups: Experimental

Frailty Clinical Trial 2023: Transcranial Ultrasound Highlights & Side Effects. Trial Name: NCT04770350 — Phase < 1

Transcranial Ultrasound (Focused Ultrasound) 2023 Treatment Timeline for Medical Study. Trial Name: NCT04770350 — Phase < 1

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Who is eligible to join this medical experiment?

"This clinical trial seeks 50 frail individuals in the age bracket between 45 and 95 years old, with a lower eligibility threshold of 60. Qualifying patients must have been clinically appraised as exhibiting signs of frailty (outside of any concurrent condition) and be rated 3 to 7 on the CSHA Clinical Frailty Scale by their physician."

Answered by AI

Is the age range for this research limited to those over 25 years?

"According to the trial's eligibility requirements, participants must lie within 45 and 95 years old. Additionally, there are 7 studies for minors under 18 and 371 clinical trials dedicated to patients aged 65 or above."

Answered by AI

Are there any vacancies remaining for this medical investigation?

"According to the clinicaltrials.gov database, this medical study is not accepting patients presently. It was uploaded on September 1st 2023 and last revised on September 26th 2022. Although enrollment for this trial has been suspended, there are still 380 other trials open for recruitment of participants at present."

Answered by AI