Snacking for Weight Loss

Overseen By Kristina T Legget, PhD

Age: 18 - 65

Sex: Any

Trial Phase: Academic

Sponsor: University of Colorado, Denver

Must not be taking: Injectables, Sulfonylureas, Meglitinides, Steroids

Disqualifiers: Nut allergy, Bariatric surgery, Eating disorder, Pregnancy, Hypertension, others

No Placebo Group All trial participants will receive the active study treatment (no placebo)

Compensation: Varies

Number of Visits: 2

Duration: 12 weeks

70 Participants Needed

What You Need to Know Before You Apply

What is the purpose of this trial?

This study plans to learn more about how different types of snacks may affect brain processes relating to eating behaviors during a diet intervention.

Who Is on the Research Team?

Kristina T Legget, PhD

Principal Investigator

University of Colorado, Denver

Are You a Good Fit for This Trial?

Inclusion Criteria

BMI at least 27 kg/m2

I am between 25 and 45 years old.

I am comfortable taking part in a weight-loss program.

Exclusion Criteria

I have had major mental health changes or treatment in the past 3 months.

Currently participating in another weight-loss study

I do not have serious hormone, kidney, liver, or blood diseases that could affect the study.

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Treatment

Participants complete a 12-week diet intervention with either walnuts or pretzels as a daily snack, with weekly meetings with study staff

12 weeks

Weekly meetings (some virtual, in-person every 2-3 weeks)

Follow-up

Participants are monitored for changes in appetite response, dietary restraint, body weight, body fat, food cravings, and reward-based eating drive

4 weeks

What Are the Treatments Tested in This Trial?

Interventions

• Snacking Effects on the Brain Response to Foods and Satiety During Dieting

How Is the Trial Designed?

Group I: Snack Type 1: Walnuts Experimental Treatment 1 Intervention

Participants will complete a 12 week diet intervention, during which they will be asked to reduce their daily caloric intake. During the diet intervention, participants in the Snack Type 1 group will be asked to eat a daily snack of walnuts, which will be provided by the study team. Participants will meet with study staff on a weekly basis during the intervention (with some meetings virtual and in-person visits every 2-3 weeks).

Group II: Snack Type 2: Pretzels Active Control 1 Intervention

Participants will complete a 12 week diet intervention, during which they will be asked to reduce their daily caloric intake. During the diet intervention, participants in the Snack Type 2 group will be asked to eat a daily snack of pretzels, which will be provided by the study team. Participants will meet with study staff on a weekly basis during the intervention (with some meetings virtual and in-person visits every 2-3 weeks).

Who Is Running the Clinical Trial?

University of Colorado, Denver

Lead Sponsor

Trials

1,842

Recruited

3,028,000+

California Walnut Commission

Collaborator

Trials

25

Recruited

36,700+