CLINICAL TRIAL

Blueberry Plus Exercise (BB-EX) for Overweight

Recruiting · 18+ · All Sexes · Durham, NC

This study is evaluating whether blueberry consumption and exercise can improve cardiovascular function, physical activity, and cognitive function in older adults.

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About the trial for Overweight

Eligible Conditions
Overweight · Overweight and Obesity · Sedentary Lifestyle · Stiffness, Arterial · Blood Pressures

Treatment Groups

This trial involves 2 different treatments. Blueberry Plus Exercise (BB-EX) is the primary treatment being studied. Participants will all receive the same treatment. Some patients will receive a placebo treatment. The treatments being tested are not being studied for commercial purposes.

Main TreatmentA portion of participants receive this new treatment to see if it outperforms the control.
Blueberry Plus Exercise (BB-EX)
DIETARYSUPPLEMENT
Control TreatmentAnother portion of participants receive the standard treatment to act as a baseline.
Blueberry Placebo Plus Exercise (P-EX)
DIETARYSUPPLEMENT

Eligibility

This trial is for patients born any sex aged 18 and older. There are 8 eligibility criteria to participate in this trial as listed below.

Inclusion & Exclusion Checklist
Mark “yes” if the following statements are true for you:
Able to walk independently
Social security number (required for compensation)
Age 60 and older
Overweight (BMI ≥25 to 35 kg/m2)
Cognitively normal (Mini-Cog score 3-5)
Own a smartphone or other mobile device capable of downloading the Garmin Connect app
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Odds of Eligibility
Unknown<50%
Be sure to apply to 2-3 other trials, as you have a low likelihood of qualifying for this one.Apply To This Trial
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Approximate Timelines

Please note that timelines for treatment and screening will vary by patient
Screening: ~3 weeks
Treatment: varies
Reporting: 0 to 12 weeks (0, 4, 8 and 12 weeks)
This trial has approximate timelines as follows: 3 weeks for initial screening, variable treatment timelines, and reporting: 0 to 12 weeks (0, 4, 8 and 12 weeks).
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Trial Expert
Connect with the researchersHop on a 15 minute call & ask questions about:
- What options you have available- The pros & cons of this trial
- Whether you're likely to qualify- What the enrollment process looks like

Measurement Requirements

This trial is evaluating whether Blueberry Plus Exercise (BB-EX) will improve 1 primary outcome, 8 secondary outcomes, and 17 other outcomes in patients with Overweight. Measurement will happen over the course of 0 weeks.

Seated blood pressure at baseline
0 WEEKS
Seated systolic and diastolic blood pressure will be measured, in duplicate, using an digital blood pressure monitor following 5 minutes of quiet sitting.
Baseline dietary intake (micronutrient intake)
0 WEEKS
Average micronutrient intake will be assessed using the Diet History Questionnaire III(NCBI) food frequency questionnaire.
Baseline dietary intake (Total calories)
0 WEEKS
Average caloric intake will be assessed using the Diet History Questionnaire III (NCBI) food frequency questionnaire.
Baseline dietary intake (macronutrient intake)
0 WEEKS
Average Macronutrient intake will be assessed using the Diet History Questionnaire III (NCBI) food frequency questionnaire.
Height at baseline
0 WEEKS
Height will be measured using a wall-mounted stadiometer.
Change from baseline in macronutrient intake at 4, 8 and 12 weeks
0 TO 12 WEEKS (0, 4, 8 AND 12 WEEKS)
Total calories will be measured using 3-day food records (participants record everything they eat and drink for three days)
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Patient Q & A Section

Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What are the signs of overweight?

There are a variety of reasons that people are overweight, and there are many signs both physical and mental. Physical signs such as obesity (excess fat on the body) and high blood pressure increase the risk of stroke or heart disease. Overweight or obese individuals may also experience lower quality of life, increased risk of cancer, impaired sleep, increased risk of anxiety, and decreased ability to exercise. Psychological signs include increased feelings of tiredness or anxiety, a desire to sleep more, and a preference to eat less than what they should eat. A weight loss program can help improve all these signs.

Anonymous Patient Answer

Can overweight be cured?

The weight loss from the combination of diet and exercise can be maintained 6 months post-intervention but the BMI continues to rise for several years. Only approximately 11 subjects can be considered to have been cured of their excess weight; the remainder would be still underweight. Overall, although diet and exercise can substantially alter the shape of the body, it is difficult to be certain whether it can be completely cleared.

Anonymous Patient Answer

What is overweight?

In most countries in Europe, as in the USA, overweight is much more common than obesity. In the developed world, overweight represents the leading risk factor for chronic disease. However, a high proportion of the population in Europe and South America was classified as obese while in the USA, this proportion is about one third lower.

Anonymous Patient Answer

What causes overweight?

People overestimate the impact of diet and lifestyle in the development of overweight. This finding is consistent with the observation that behavioral factors are more effective in leading to an increase in weight than a decrease in physical activity. People's overconfidence of their ability to reduce weight is a barrier for adopting a more healthy lifestyle. In the context of nutrition, overweight is a modifiable and potentially treatable risk factor for hypertension, ischemic heart disease, and cancer.

Anonymous Patient Answer

What are common treatments for overweight?

In a European country, the overall use of medications is similar to the rates reported in the literature for the United States. However, overweight patients were more likely to receive non-standard treatment in comparison with the US population, particularly weight loss-related treatment such as surgery or surgery-related medication.

Anonymous Patient Answer

How many people get overweight a year in the United States?

About 6.4 million Americans have high blood pressure, and about 18% of the US population have blood pressure that is high enough to make it a disease. These data, taken together, indicate that more than 7.2 million Americans are at risk of developing hypertension. This implies that over half (53%) of the adult population and 40% of high school students in the U.S. have high blood pressure.

Anonymous Patient Answer

What are the common side effects of blueberry plus exercise (bb-ex)?

Blueberry plus walking was well tolerated in this study. In addition to being effective in reducing blood pressure and total cholesterol, blueberry plus walking was also well tolerated.

Anonymous Patient Answer

What is blueberry plus exercise (bb-ex)?

Recent findings demonstrated an improvement in glucose homeostasis and a better lipid profile when the meal after exercise is a high-fat, low-carbohydrate blueberry-flavored beverage relative to exercise alone. It is proposed that the beverage may contribute to the improvement of the lipid profile without negatively impacting exercise-induced gains in insulin sensitivity, body weight, lean body mass and physical endurance.

Anonymous Patient Answer

What does blueberry plus exercise (bb-ex) usually treat?

The present study suggests that a short term intake regimen of two berries may not be sufficient for increasing the aerobic capacity of overweight-to-morbidly obese individuals. However, if the berry intake regimen in the study was feasible, it might have significant benefit in the improvement of some metabolic alterations associated with the overweight-to-morbidly obese state. Further studies are needed to elucidate the most efficient berry intake regimen for improving both physical and metabolic fitness in overweight-to-morbidly obese individuals.

Anonymous Patient Answer

Have there been any new discoveries for treating overweight?

There have always been ideas and new treatments for overweight. There is currently work to discover new ways to treat overweight and to decrease risk factors and improve the outcomes. We will see if we can prevent obesity. This can be done better by decreasing stress, improving our overall diets by changing food choices and having an overall healthier lifestyle.

Anonymous Patient Answer

What is the primary cause of overweight?

The primary cause of overweight is, undoubtedly, genetic makeup, meaning family history, but it is estimated that 75-80 percent of weight gain in women is related to lifestyle factors. There appears to be a strong association between excessive eating and weight gain; if any amount of food can gain a person more than 5 kg, they will eventually gain more than 5 kg. Obesity is associated with more unhealthy lifestyles in women.

Anonymous Patient Answer

What is the latest research for overweight?

There is a lack of research regarding the treatment and management of overweight. We need to have knowledge about what treatments and management are most effective for overweight patients. The information should also be provided in ways understandable to patients.

Anonymous Patient Answer
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