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Avocado Diet for Obesity (PATH-2 Trial)

N/A

Recruiting

Led By Hannah Holscher, PhD, RD

Research Sponsored by University of Illinois at Urbana-Champaign

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up 4 week

Awards & highlights

PATH-2 Trial Summary

This trial studies how eating avocados affects gut health & thinking in adults with overweight & obesity. Participants eat provided meals with & without avocados & complete memory & thinking tests.

Who is the study for?

Adults aged 25-74 with a BMI of 25 or higher can join this study. They must be able to deliver stool samples quickly after going to the bathroom and have good vision (with glasses if needed). People with avocado allergies, food intolerances, recent mothers, those on certain medications for cholesterol or blood sugar, or with specific past surgeries or diseases like liver issues and diabetes cannot participate.Check my eligibility

What is being tested?

The PATH-2 trial is exploring how eating avocados affects gut health and brain function in overweight adults. Participants will eat meals provided by the study that include avocados for three periods lasting four weeks each. They'll give stool samples and play computer games to test memory and thinking at each period's end.See study design

What are the potential side effects?

Since this trial involves consuming avocados as part of a diet plan rather than medication, side effects may be minimal but could include digestive discomfort due to dietary changes.

PATH-2 Trial Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ 4 week

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~4 week

This trial's timeline: 3 weeks for screening, Varies for treatment, and 4 week for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Concentration of fecal SCFA

Concentration of fecal bile acids

Fecal microbial genes

+1 more

Secondary outcome measures

Cognitive function

Digestive health using stool records/Bristol Stool Scale

Subjective gastrointestinal tolerance via questionnaire

Other outcome measures

Fecal metabolites

Fecal microbiome

Fecal pH

+2 more

PATH-2 Trial Design

3Treatment groups

Experimental Treatment

Active Control

Placebo Group

Group I: AvocadoExperimental Treatment1 Intervention

The experimental treatment will contain an avocado. Avocados will be consumed daily for 4 weeks.

Group II: Fiber + OilActive Control1 Intervention

The active comparator will have a snack that mimics the fiber and fatty acid composition found in avocados and will be consumed daily for 4 weeks.

Group III: Standard American DietPlacebo Group1 Intervention

The sham comparator contains foods and beverages of a standard American diet and will be consumed daily for 4 weeks.

Do I qualify?Apply below to find out

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Who is running the clinical trial?

University of Illinois at Urbana-ChampaignLead Sponsor

189 Previous Clinical Trials

37,340 Total Patients Enrolled

23 Trials studying Obesity

2,490 Patients Enrolled for Obesity

Hannah Holscher, PhD, RDPrincipal InvestigatorUniversity of Illinois Urbana Champaign

1 Previous Clinical Trials

24 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Are elderly individuals excluded from participation in this trial?

"According to the trial's requirements, candidates must be between 25 and 74 years old in order to participate."

Answered by AI

Is the application window for this research study still ajar?

"Data sourced from clinicaltrials.gov reveals that recruitment is still underway for this experiment, which was first published on July 11th 2023 and recently updated on October 11th of the same year."

Answered by AI

How many individuals have enrolled in this research endeavor?

"Affirmative. Data hosted on clinicaltrials.gov confirms that this medical study, initially posted on July 11th 2023, is actively searching for participants to join the trial. A total of 45 volunteers are required from 1 site."

Answered by AI

Are there any specific criteria to qualify for participation in this research?

"This research is recruiting 45 individuals, aged 25 to 74 years old, with a BMI of at least 25 kg/m2. Furthermore, participants must possess 20/20 or corrected vision and be able to drop off the fecal sample within 15 minutes after defecation."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Persea Americana for Total Health (PATH)-2

Hannah Holscher 2023. "Persea Americana for Total Health (PATH)-2". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT05941728.