Ultrasound Microvessel Imaging for Ovarian Cancer
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial explores a new ultrasound technique called ultrasound microvessel imaging (UMI) to better evaluate ovarian and adnexal lesions. The goal is to determine if UMI can more accurately detect small blood vessels, which might indicate a higher cancer risk compared to traditional ultrasounds. This advancement could aid in diagnosing ovarian cancer, known as the deadliest gynecologic cancer, often detected in advanced stages. The trial suits women scheduled for surgery to treat ovarian or adnexal lesions. As an unphased trial, participants can contribute to groundbreaking research that could enhance early cancer detection.
Will I have to stop taking my current medications?
The trial does not specify if you need to stop taking your current medications, but it excludes those undergoing chemotherapy or targeted therapy. It's best to discuss your specific medications with the trial coordinator.
What prior data suggests that ultrasound microvessel imaging is safe for evaluating ovarian and adnexal lesions?
Research has shown that ultrasound microvessel imaging (UMI) offers a promising new method for examining blood flow in the ovaries. This technique provides better visualization of small blood vessels than traditional ultrasounds, aiding doctors in detecting ovarian tumors more easily.
Regarding safety, UMI is comparable to regular ultrasound. Ultrasounds are known to be safe and are widely used in medical care. Studies have not reported any harmful side effects specific to UMI, suggesting it is well-tolerated, similar to regular ultrasound methods.
Therefore, for those considering joining a trial using UMI, research indicates it should be as safe as a regular ultrasound.12345Why are researchers excited about this trial?
Researchers are excited about Ultrasound Microvessel Imaging (UMI) for ovarian cancer because it offers a new way to visualize blood vessels within tumors using advanced ultrasound techniques. Unlike standard imaging methods, which may not capture detailed blood flow information, UMI provides a clearer picture of the microvessels, potentially leading to earlier and more accurate detection. This method could revolutionize diagnostic capabilities and improve treatment planning by allowing doctors to assess tumor characteristics non-invasively and in real-time.
What evidence suggests that ultrasound microvessel imaging is effective for evaluating ovarian cancer?
Research shows that ultrasound microvessel imaging (UMI), which participants in this trial will undergo during a standard transvaginal ultrasound procedure, might better detect small blood vessels in ovarian and nearby areas than regular ultrasound methods. Studies have found that increased blood flow can indicate a higher risk of cancer. One study, in particular, found clear differences in the appearance of benign (non-cancerous) and malignant (cancerous) ovarian tumors using UMI. This suggests UMI might better distinguish between these types. Consequently, UMI could potentially enhance the accuracy of ovarian cancer diagnosis, which is crucial because early detection can greatly improve survival chances.16789
Who Is on the Research Team?
Shigao D. Chen, PhD
Principal Investigator
Mayo Clinic
Are You a Good Fit for This Trial?
This trial is for patients scheduled for surgery to treat ovarian or adnexal lesions. It's aimed at improving diagnosis of these conditions, which could include benign tumors or ovarian cancer. Participants should be those who are already planned to undergo surgical treatment as part of their standard care.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Diagnostic Imaging
Participants undergo ultrasound microvessel imaging (UMI) during standard transvaginal ultrasound imaging procedure
Follow-up
Participants are monitored for safety and effectiveness after diagnostic imaging
What Are the Treatments Tested in This Trial?
Interventions
- Ultrasound Microvessel Imaging
Trial Overview
The study is testing a new ultrasound technique called Ultrasound Microvessel Imaging (UMI) against the traditional transvaginal ultrasound method. The goal is to see if UMI can better detect small blood vessels in ovarian and adnexal lesions, potentially indicating a higher risk of cancer.
How Is the Trial Designed?
1
Treatment groups
Experimental Treatment
Patients undergo UMI during standard transvaginal ultrasound imaging procedure on study.
Find a Clinic Near You
Who Is Running the Clinical Trial?
Mayo Clinic
Lead Sponsor
Citations
Ultrasound Microvessel Imaging for the Evaluation of ...
This clinical trial studies how well ultrasound microvessel imaging (UMI) works in evaluating ovarian and adnexal lesions in patients who are ...
Study on the Characteristics of Contrast-Enhanced ...
Our results showed clear differences in enhancement patterns between benign and malignant ovary tumors or tumor-like lesions. The PI and AUC in the malignant ...
Enhancement of Ovarian Tumor Detection With αvβ3 ...
The goal of this study was to examine the feasibility of αvβ 3 integrin single bond targeted molecular imaging agent in enhancing the detection of spontaneous ...
Imaging in oncology - 2025 - Obstetrics and Gynecology - Wiley
High-grade serous ovarian cancer (HGSOC) is the most aggressive subtype of ovarian cancer, with a 5-year survival rate of 47%. Given HGSOC's ...
Screening for ovarian cancer: imaging challenges and ...
Across all screen-detected invasive epithelial ovarian cancers, the 5-year survival rate was 74.8% ± 6.6% compared with 53.7% ± 2.3% for unscreened patients ...
Applications of Artificial Intelligence and Multimodal ...
Single-mode ultrasound imaging often fails to provide sufficient diagnostic information for ovarian cancer. Multimodal ultrasound combines ...
Diagnostic Value of Two-Dimensional Transvaginal ...
Contrast-enhanced ultrasound technology can be used to evaluate the blood vessels of ovarian tumors, improve the sensitivity of ultrasound to the display of ...
Enhancement of Ovarian Tumor Detection by DR6 ...
This study showed that DR6-targeted imaging agents bind with their targets expressed by the malignant cells and tumor-associated microvessels in ovarian tumors ...
Is three-dimensional ultrasonography a valuable ...
Ovarian cancer (OC) is a major concern for women's health, accounting for 3.4% of female cancer cases and with a mortality rate of 4.7% (1).
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