Cognitive-Behavioral Intervention for Osteoarthritis, Knee

Phase-Based Estimates
1
Effectiveness
1
Safety
UF Health at the University of Florida, Gainesville, FL
Osteoarthritis, Knee
Cognitive-Behavioral Intervention - Behavioral
Eligibility
18+
All Sexes
Eligible conditions
Osteoarthritis, Knee

Study Summary

This study is evaluating whether a specific type of therapy may help reduce pain for individuals with knee osteoarthritis.

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Treatment Effectiveness

Effectiveness Estimate

1 of 3

Study Objectives

This trial is evaluating whether Cognitive-Behavioral Intervention will improve 1 primary outcome in patients with Osteoarthritis, Knee. Measurement will happen over the course of Baseline; Day 2.

Baseline; Day 2
Change in Pain Catastrophizing Scale (PCS)

Trial Safety

Safety Estimate

1 of 3

Trial Design

2 Treatment Groups

Pain Education Group
Pain Catastrophizing Reduction Group

This trial requires 104 total participants across 2 different treatment groups

This trial involves 2 different treatments. Cognitive-Behavioral Intervention is the primary treatment being studied. Participants will all receive the same treatment. There is no placebo group. The treatments being tested are not being studied for commercial purposes.

Pain Catastrophizing Reduction Group
Behavioral
This group will be assigned to a 30-minute, single-session cognitive-behavioral intervention designed to reduce pain catastrophizing.
Pain Education Group
Behavioral
This group will receive general information about the neurobiology of pain and knee OA.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Cognitive-Behavioral Intervention
2019
N/A
~200

Trial Logistics

Trial Timeline

Approximate Timeline
Screening: ~3 weeks
Treatment: Varies
Reporting: baseline; day 2
This trial has the following approximate timeline: 3 weeks for initial screening, variable treatment timelines, and roughly baseline; day 2 for reporting.

Closest Location

UF Health at the University of Florida - Gainesville, FL

Eligibility Criteria

This trial is for patients born any sex aged 18 and older. There is one eligibility criterion to participate in this trial as listed below.

Mark “yes” if the following statements are true for you:
Symptomatic knee OA

Patient Q&A Section

Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is cognitive-behavioral intervention safe for people?

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CBT for people with [knee osteoarthritis](https://www.withpower.com/clinical-trials/knee-osteoarthritis) is a safe intervention. The high level of adherence shown in this study is in agreement with previous studies of CBT for knee osteoarthritis. These data support the recommendation to screen people for knee osteoarthritis, but not necessarily to offer CBT to people with osteoarthritis because of the low level of evidence.

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Can osteoarthritis, knee be cured?

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The best current treatments do not result in complete remission of osteoarthritis. Nevertheless, with proper treatments patients may significantly reduce pain. Nevertheless, in most cases, knee surgery does not result in a complete cure.

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What is osteoarthritis, knee?

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The knee is a site of rapid change during human life and is a common site of osteoarthritis. The knee is a key joint in the lower limb. People often think that osteoarthritis is only a disease of the older person or that elderly people are more likely to suffer from the condition. It often affects people from between the ages of 35 and 80. It often affects women more than men. Osteoarthritis pain and swelling may affect most people during their lives but the condition can be more dangerous and debilitating if left undiagnosed.

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What are common treatments for osteoarthritis, knee?

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The mainstay of [osteoarthritis](https://www.withpower.com/clinical-trials/osteoarthritis) treatment is analgesics, especially NSAIDs, and physical therapy may be recommended to help patients function better. There are no known cures or medications to halt the progression of the disease. The aim of treatment is to prevent further symptomatic OA progression and disability.

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What are the signs of osteoarthritis, knee?

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Clinical findings including joint space widening, osteophytes, and radiologic signs and symptoms of [osteoarthritis](https://www.withpower.com/clinical-trials/osteoarthritis), knee, are reliable indicators of the diagnosis of knee OA. We have not yet evaluated the ability of these findings to predict the course of knee OA.

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How many people get osteoarthritis, knee a year in the United States?

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Approximately 22 million people will be diagnosed with osteoarthritis, knee in the United States in 2020. Furthermore, approximately 13 million people will be diagnosed with patellar and femoral osteoarthrosis in 2020. There is a disparity between the numbers of these people per year. This is due to many factors one of which includes access to care. If access to care were improved the number of people diagnosed with patellar and femoral osteoarthrosis in the country could be reduced by approximately 60%.

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What causes osteoarthritis, knee?

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Osteoarthritis is usually seen in the knees of middle-aged women. It most commonly develops after high-impact sports. The knee joints are the most commonly affected joints; however, the joints of the arms and hands may be affected. It is also more prevalent in the hand than the foot of the affected individual. Other joints may be affected and cause similar presentations to osteoarthritis of the knee. Arthritis is the joint disease which can affect your lower back, hips, and other joints.

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What is the latest research for osteoarthritis, knee?

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It is quite difficult to predict the incidence trend of osteoarthritis in the population due to the large amount of variation in treatment and study designs over study time. Data from a recent study reported herein highlight the importance of understanding the risk factors of osteoarthritis, conducting randomized controlled trials (RCT), and implementing standardized measurements for monitoring of osteoarthritis.

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Have there been any new discoveries for treating osteoarthritis, knee?

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It is important to note that most of the new treatments are for treating OA of other joints in the body not knee. No new treatments have been shown to have good results for treating KOA, but there have been some recent innovations that have been shown to be beneficial. There is limited evidence on the effectiveness of the treatments, with more research needed to make recommendations. These treatments have been used to try to treat both focal or diffuse KOA with osteoarthritic symptoms and also to treat acute or chronic knee pain.

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What are the common side effects of cognitive-behavioral intervention?

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Data from a recent study of this study demonstrate that there are no common negative effects of a short-term cognitive-behavioral intervention on the knee. These side effects may be minimized by educating patients about these side effects and by conducting periodic follow-up assessments.

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Does cognitive-behavioral intervention improve quality of life for those with osteoarthritis, knee?

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Cognitive-behavioral intervention improved physical function in the participants with knee OA, and had a positive impact on HR–QoL and pain. Cognitive-behavior psychosocial intervention may also be effective in reducing disability in persons with knee OA.

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Have there been other clinical trials involving cognitive-behavioral intervention?

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Overall, the results of this study are consistent with the previous trials using CBT. Although no study has been specifically designed to examine the effects of CBT on the outcomes of osteoarthritis, these findings suggest that CBT is useful for treating knee osteoarthritis.

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