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Non-Invasive Brain Stimulation

Transcranial Magnetic Stimulation for Chronic Pain

N/A

Waitlist Available

Research Sponsored by Northwestern University

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up 1 to 12 weeks (end of the study)

Awards & highlights

Study Summary

This trial will test whether TMS can help relieve pain for people with knee osteoarthritis by examining changes in hippocampal network connectivity and pain levels.

Eligible Conditions

Chronic Pain
Osteoarthritis

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ 1 to 12 weeks (end of the study)

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~1 to 12 weeks (end of the study)

This trial's timeline: 3 weeks for screening, Varies for treatment, and 1 to 12 weeks (end of the study) for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Pain ratings (Numeric Rating Scale)

Secondary outcome measures

Adverse events

Brain biomarkers and psychological indicators of rTMS effects and pain relief

Global impression of change

+1 more

Trial Design

3Treatment groups

Experimental Treatment

Active Control

Placebo Group

Group I: Stimulation Modality 1Experimental Treatment1 Intervention

Repetitive TMS will be applied at 100% resting motor threshold intensity to a region of interest located in the parietal cortex, that will be determined based on its connectivity with the hippocampus.

Group II: Stimulation Modality 3Active Control1 Intervention

The stimulation will be delivered over the motor cortex contralateral to the predominant painful region, i.e., right motor cortex stimulation if left knee pain. The stimulation intensity will be set at 80% of the resting motor threshold.

Group III: Stimulation Modality 2Placebo Group1 Intervention

Parameters will be identical to the modality 1, except that the coil will be flipped over.

Treatment

First Studied

Drug Approval Stage

How many patients have taken this drug

Transcranial Magnetic Stimulation

2017

Completed Phase 4

~730

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Who is running the clinical trial?

Northwestern UniversityLead Sponsor

1,585 Previous Clinical Trials

917,231 Total Patients Enrolled

12 Trials studying Chronic Pain

3,859 Patients Enrolled for Chronic Pain

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Are patients needed for this research project?

"From what is published on clinicaltrials.gov, it seems as though this trial is searching for participants at the moment. The initial posting was on November 15th 2021 with the most recent edit happening on January 3rd 2022."

Answered by AI

Who would this trial be a good fit for?

"Up to 35 adults suffering from chronic pain can participate in this study, regardless of their age, gender, or ethnicity. The most notable requirements are: having knee pain every day for at least 6 months; being able to use the PainApp; and being healthy enough to not pose a risk to the research."

Answered by AI

Is this research being conducted with elderly individuals?

"This study's requirements for participants state that they must be between 18-80 years old. There are 72 clinical trials targeting patients below the age of 18 and 1053 studies for people 65 and over."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

rTMS for Relieving Chronic OA Pain

Apkar Apkarian 2021. "rTMS for Relieving Chronic OA Pain". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT05097729.