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Behavioral Intervention
Tai Chi for Osteoarthritis Pain Management
N/A
Waitlist Available
Led By Chwan-Li Shen
Research Sponsored by Texas Tech University Health Sciences Center
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
WOMAC pain score ≥ 50 on at least 1 of the 5 questions in pain subscale (range of 0 to 100, with higher scores indicating greater pain)
Diagnosed with the following symptoms associated with knee OA based on American College of Rheumatology clinical classification criteria for osteoarthritis (Peat 2006): Pain in the knee and at least 3 of the following: over 50 years of age, less than 30 minutes of morning stiffness, crepitus on active motion, bony tenderness, bony enlargement, or no palpable warmth of synovium.
Timeline
Screening 3 weeks
Treatment Varies
Follow Up changes from baseline sf-36 results at 8 weeks
Awards & highlights
Study Summary
This trial is to see if Tai Chi has an effect on plasma endocannabinoid levels and other things in women with knee OA.
Who is the study for?
This trial is for postmenopausal women with knee osteoarthritis pain who can read English and have an MRI scan. They must have knee pain with specific symptoms like morning stiffness or bony tenderness, and a certain level of pain on the WOMAC scale. Women who've recently done mind-body practices or had certain treatments for knee OA cannot join.Check my eligibility
What is being tested?
The study tests how Tai Chi exercise over 8 weeks affects substances in the blood related to inflammation and brain factors, as well as changes in brain connectivity and improvements in function and clinical outcomes for women suffering from knee osteoarthritis.See study design
What are the potential side effects?
Tai Chi is generally considered safe but may include muscle soreness, joint strain, or falls if not performed correctly. Since it's a low-impact exercise, serious side effects are rare.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowSelect...
I have a pain score of 50 or more on the WOMAC scale.
Select...
I am over 50, have knee pain, stiffness under 30 mins, knee sounds, tenderness, or swelling but no warmth.
Select...
I am a woman who has gone through menopause.
Timeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ changes from bseline endocannabinoid levels at 8 weeks
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~changes from bseline endocannabinoid levels at 8 weeks
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Primary outcome measures
endocannabinoid
oxylipins
Secondary outcome measures
BDNF
Pain assessment
Quality of life assessment
+4 moreTrial Design
1Treatment groups
Experimental Treatment
Group I: Tai Chi interventionExperimental Treatment1 Intervention
24-form Yang style Tai Chi
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Tai chi exercise
Completed Phase 1
Unknown
Find a Location
Who is running the clinical trial?
Texas Tech University Health Sciences CenterLead Sponsor
104 Previous Clinical Trials
10,741 Total Patients Enrolled
2 Trials studying Osteoarthritis
10 Patients Enrolled for Osteoarthritis
Chwan-Li ShenPrincipal InvestigatorTexas Tech University Health Sciences Center
Media Library
Eligibility Criteria:
This trial includes the following eligibility criteria:- I haven't had steroid injections or knee surgery in the last 3 months.I have a pain score of 50 or more on the WOMAC scale.I need help to walk, like a cane or walker.I've had a knee injection for arthritis in the last 6 months.I have severe health issues like dementia or heart disease that limit my activities.I am over 50, have knee pain, stiffness under 30 mins, knee sounds, tenderness, or swelling but no warmth.I am a woman who has gone through menopause.I have practiced mind-body techniques or had physical therapy for knee OA recently.You are able to have a special type of body scan called an MRI.I have a condition like MS, Parkinson's, or diabetes with neuropathy affecting my balance or sensation.
Research Study Groups:
This trial has the following groups:- Group 1: Tai Chi intervention
Awards:
This trial has 1 awards, including:- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
Timeline:
This trial has the following timeline:- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
What is the desired outcome of this medical research endeavor?
"The objective of this trial is to assess changes from baseline endocannabinoid and oxylipin levels after 8 weeks. Secondary outcomes include measuring plasma brain-derived neurotrophic factor, analyzing expression of endocannabioid receptors on peripheral blood mononuclear cells, and examining white matter connectivity/efficiency in the brain via diffusion tensor imaging. Blood collection will involve a Leucosep tube with Ficoll-Paque while DTI images are obtained using echo planar imaging at 60 directions with b-value 1000s/mm2."
Answered by AI
Is this research endeavor open to recruitment at present?
"As per information on clinicaltrials.gov, recruitment for this trial has been suspended. Initially posted in September 2019 and last updated in late 2022, it is not at present soliciting patients; however, there are 694 other trials actively recruiting right now."
Answered by AI
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