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Electrolyte Solution

Saline Infusion for POTS

N/A

Waitlist Available

Led By Satish R Raj, MD MSCI

Research Sponsored by Vanderbilt University

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up 24h and then hourly post saline load

Awards & highlights

Study Summary

This trial will test whether people with chronic orthostatic intolerance or postural orthostatic tachycardia syndrome (OI/POTS) have difficulty conserving sodium, compared to healthy control subjects.

Who is the study for?

This trial is for individuals diagnosed with orthostatic intolerance or POTS by the Vanderbilt Autonomic Dysfunction Center, as well as healthy controls. It's not suitable for those with an obvious or sudden cause of rapid heartbeat, high blood pressure (over 145/95 or on medication), abnormal EKG results, or if pregnant.Check my eligibility

What is being tested?

The study aims to see if patients with chronic orthostatic intolerance or POTS have trouble conserving sodium in their urine compared to healthy people. Participants will receive normal saline (0.9%) during the trial.See study design

What are the potential side effects?

Receiving normal saline is generally safe but can sometimes cause mild side effects like a cool feeling at the injection site, a salty taste in the mouth, or rarely more serious reactions.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ 24h and then hourly post saline load

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~24h and then hourly post saline load

This trial's timeline: 3 weeks for screening, Varies for treatment, and 24h and then hourly post saline load for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Urinary Na excretion

Secondary outcome measures

Catecholamine levels

Trial Design

1Treatment groups

Experimental Treatment

Group I: 1Experimental Treatment1 Intervention

saline infusion for sodium loading

Do I qualify?Apply below to find out

Find a Location

Who is running the clinical trial?

Vanderbilt UniversityLead Sponsor

703 Previous Clinical Trials

6,143,317 Total Patients Enrolled

13 Trials studying Postural Orthostatic Tachycardia Syndrome

752 Patients Enrolled for Postural Orthostatic Tachycardia Syndrome

National Center for Research Resources (NCRR)NIH

537 Previous Clinical Trials

316,986 Total Patients Enrolled

2 Trials studying Postural Orthostatic Tachycardia Syndrome

200 Patients Enrolled for Postural Orthostatic Tachycardia Syndrome

National Heart, Lung, and Blood Institute (NHLBI)NIH

3,833 Previous Clinical Trials

47,306,466 Total Patients Enrolled

10 Trials studying Postural Orthostatic Tachycardia Syndrome

460 Patients Enrolled for Postural Orthostatic Tachycardia Syndrome

Media Library

Normal Saline (Electrolyte Solution) Clinical Trial Eligibility Overview. Trial Name: NCT00581633 — N/A

Postural Orthostatic Tachycardia Syndrome Research Study Groups: 1

Postural Orthostatic Tachycardia Syndrome Clinical Trial 2023: Normal Saline Highlights & Side Effects. Trial Name: NCT00581633 — N/A

Normal Saline (Electrolyte Solution) 2023 Treatment Timeline for Medical Study. Trial Name: NCT00581633 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

To whom is this investigation open?

"Prospective patients must demonstrate orthostatic intolerance and fit within the specified age parameters (18-65) to enter this clinical trial. Currently, 30 participants are being recruited for the study."

Answered by AI

Is enrollment for this research endeavor currently open?

"According to the latest update posted on clinicaltrials.gov, this particular medical trial is no longer accepting applicants; however, there are presently 125 other studies with open enrollment requirements. Originally published in February 2007, it appears that its most recent iteration was updated September 12th 2022."

Answered by AI