PerioPull™ for Oral Hygiene

Overseen By David Brady, ND, DC

Age: 18+

Sex: Any

Trial Phase: Academic

Sponsor: Designs for Health

Disqualifiers: Tobacco smoker, Pregnant, Oral infection, others

No Placebo Group All trial participants will receive the active study treatment (no placebo)

Compensation: Varies

Number of Visits: 3

Duration: 12 weeks

18 Participants Needed

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial aims to evaluate how PerioPull™, an oil rinse, affects dental health in adults. Participants will use the oil rinse daily for 12 weeks to determine its impact on dental health indicators, such as plaque and gum health. It may suit individuals with noticeable plaque or gum issues, provided they have no severe oral infections and maintain their current dental hygiene routine. As an unphased trial, this study offers participants the chance to explore a potentially beneficial dental health treatment.

Do I need to stop taking my current medications for the trial?

The trial protocol does not specify whether you need to stop taking your current medications. However, you must maintain your current dental hygiene routine.

What prior data suggests that PerioPull™ is safe for oral hygiene?

Research has shown that PerioPull™, an oil rinse product, is available for purchase and used for oral care, indicating it is generally well-tolerated. According to the product information, PerioPull™ helps maintain healthy gums and teeth. Users swish it in their mouths, and it is not considered dangerous. Although detailed safety data is not provided, its sale through dental offices and consumer use suggests it is considered safe in practice.

To minimize potential risks, users should follow the label directions and check for personal allergies or sensitivities to the ingredients before use. ^{1 2 3 4 5}

Why are researchers excited about this trial?

Unlike traditional oral hygiene treatments like toothpaste and mouthwash, which often contain chemical ingredients, PerioPull™ is unique because it uses a natural oil-based approach. The treatment involves swishing oil in the mouth, which can potentially offer a gentler alternative for maintaining oral health. Researchers are excited about PerioPull™ because it allows for prolonged contact with teeth and gums, which might enhance its effectiveness in reducing oral bacteria and improving gum health. This method presents a novel delivery system that could appeal to those seeking more natural oral care solutions.

What evidence suggests that PerioPull™ is effective for improving dental health?

Research suggests that oil rinses like PerioPull™ might improve dental health. Studies have shown that similar products can reduce gum disease and bleeding. Oil rinses help decrease plaque, a sticky layer of bacteria on the teeth. Early findings indicate that people using oil rinses may experience better oral health over time. Although PerioPull™ is already available and used by some dentists, this trial continues to explore its full impact. ^{3 4 6 7 8}

Are You a Good Fit for This Trial?

This trial is for adults interested in improving their dental health. Participants should be looking to test the effects of a new oil rinse product, PerioPull™, which is available through clinicians' offices. Specific eligibility criteria are not provided.

Inclusion Criteria

Plaque index of at least 1

Gingival index of at least 1

Able to understand and write English

Exclusion Criteria

I am currently using products that contain the same nutrients or herbs as the study product.

I have taken antibiotics in the last 3 months.

Currently pregnant or lactating women or women planning to become pregnant in the next 12 weeks

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Treatment

Participants use PerioPull™ oil rinse daily for 12 weeks to improve dental health markers

12 weeks

3 visits (in-person)

Follow-up

Participants are monitored for safety and effectiveness after treatment

4 weeks

What Are the Treatments Tested in This Trial?

Interventions

• PerioPull™

Trial Overview The study tests PerioPull™, an oil rinse product sold by dentists, over 12 weeks to see if it improves markers of dental health like gum disease and plaque levels.

How Is the Trial Designed?

Group I: PerioPull™ Experimental Treatment 1 Intervention

Participants will swish 1 teaspoon (approx. 5 mL) of oil in the mouth for a minimum of 5 minutes after their normal brushing routine, as is suggested on the label of the bottle. They will spit out the oil and not rinse to allow for longer contact to the teeth and gums. This will be once a day for 12 weeks.

Who Is Running the Clinical Trial?

Designs for Health

Lead Sponsor

Trials

3

Recruited

90+

Citations

1. trialx.com trialx.com/clinical-trials/listings/312530/a-pilot-study-of-a-commercially-available-oil-rinse-product-periopulltm-on-markers-of-dental-health/

A Pilot Study of a Commercially-available Oil Rinse ... The research team hypothesizes that PerioPull™ will improve a variety of validated markers of dental health that are commonly used in clinical ...

2. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov/articles/PMC11431985/

The Effectiveness of Individualized Oral Hygiene Education ... The results indicated a significant improvement in the oral hygiene of patients in the Prophylaxis Concept groups, leading to sustainable oral health without ...

3. withpower.com withpower.com/trial/phase-oral-health-3-2024-71994

PerioPull™ for Oral Hygiene Trial Overview The study tests PerioPull™, an oil rinse product sold by dentists, over 12 weeks to see if it improves markers of dental health like gum disease ...

4. centerwatch.com centerwatch.com/clinical-trials/listings/condition/326/oral-medicine

Oral Medicine Clinical Research Trials The primary outcomes will be caries increment of the adolescents 2-year post-intervention. Change in oral health self-efficacy and behaviors, dental plaque and ...

5. jdh.adha.org jdh.adha.org/content/96/3/21

A 12-week virtually supervised clinical trial After 12 weeks, gingivitis and gingival bleeding were significantly reduced in the BF group (9.2%, p=0.013 and 17.5%, p=0.003, respectively), however there were ...

6. designsforhealth.com designsforhealth.com/products/periopull/?srsltid=AfmBOorRlY99o4xOMb7twBEaTeXod6owu9AAEWsPjtEFkhhOr6XY8r34

PerioPull™ | Superior Supplement Products - Science First An oil-pulling product to support oral hygiene and periodontal health, including healthy gums, teeth, and oral microbial balance.*

7. amazon.com amazon.com/Designs-Health-PerioPull-Bromelain-Coenzyme/dp/B0BSWB2TN4

Designs for Health PerioPull - Pulling Oil for Teeth and ... Swish, Floss & Brush - PerioPull oral hygiene rinse may help support oral hygiene and periodontal health when used as recommended. ... Consumer Health Data ...

8. henryschein.ca henryschein.ca/MSDS/105Y822_CA_MSDS_01.pdf

SAFETY DATA SHEET Although the product is not classified as dangerous, we recommend you to take the safety advice given below into account. 2.2. Label elements. According to ...