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Smartphone-Based Digital Intervention for Opioid Use Disorder

N/A
Waitlist Available
Led By Nicholas C Jacobson, PhD
Research Sponsored by Trustees of Dartmouth College
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 56 days (or 8-weeks)
Awards & highlights

Study Summary

This trial will test the feasibility and effectiveness of a digital intervention for anxiety and depression among people receiving medication treatment for opioid use disorder.

Eligible Conditions
  • Opioid Use Disorder
  • Depression
  • Anxiety Disorders

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~56 days (or 8-weeks)
This trial's timeline: 3 weeks for screening, Varies for treatment, and 56 days (or 8-weeks) for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Change in anxiety symptoms as assessed by Generalized Anxiety Disorder- Q-IV Scale
Change in depressive symptoms as assessed by Patient Health Questionnaire-9
Positive Test for Opioids
Secondary outcome measures
Difficulties in emotion regulation using the Modified Difficulties in Emotion Regulation Scale (DERS)
Estimates of Activities
Estimates of Light Exposure
+4 more

Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: Smartphone Digital Intervention GroupExperimental Treatment1 Intervention
The Smartphone Digital Intervention Group is the experimental group. Participants randomized to this group will download the smartphone intervention and be asked to use the intervention four times per week for four weeks ( 16 digital sessions). The smartphone digital intervention will also continuously collect passive sensing data. The smartphone digital intervention will be designed to treat anxiety and depression by providing informational videos to help participants treat these symptoms. These videos include information about physical activity, muscle relaxation, and other proven helpful interventions to help with anxiety and depression.
Group II: Wait list Control ConditionActive Control1 Intervention
The wait list control condition will not receive the digital intervention treatment for the duration of the study. They will still provide urine samples during the study. Participants assigned to this condition will be able to access the digital intervention after their participation in the study.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Smartphone-Based Digital Intervention
2021
N/A
~70

Find a Location

Who is running the clinical trial?

Trustees of Dartmouth CollegeLead Sponsor
23 Previous Clinical Trials
10,622 Total Patients Enrolled
Nicholas C Jacobson, PhDPrincipal InvestigatorDartmouth College
1 Previous Clinical Trials
210 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
World PsychiatryJournal
The Efficacy of Smartphone-based Mental Health Interventions for Depressive Symptoms: A Meta-analysis of Randomized Controlled Trials
Firth, Joseph, John Torous, Jennifer Nicholas, Rebekah Carney, Abhishek Pratap, Simon Rosenbaum, and Jerome Sarris. 2017. “The Efficacy of Smartphone-based Mental Health Interventions for Depressive Symptoms: A Meta-analysis of Randomized Controlled Trials”. World Psychiatry. Wiley. doi:10.1002/wps.20472.
AddictionJournal
Computer‐based Psychological Treatment for Comorbid Depression and Problematic Alcohol And/or Cannabis Use: A Randomized Controlled Trial of Clinical Efficacy
Kay‐Lambkin, Frances J., Amanda L. Baker, Terry J. Lewin, and Vaughan J. Carr. 2009. “Computer‐based Psychological Treatment for Comorbid Depression and Problematic Alcohol And/or Cannabis Use: A Randomized Controlled Trial of Clinical Efficacy”. Addiction. Wiley. doi:10.1111/j.1360-0443.2008.02444.x.
Addictive BehaviorsJournal
Anxiety Sensitivity Moderates Drug Cravings in Response to Induced Negative Affect in Opioid Dependent Outpatients
Stathopoulou, Georgia, Mark H. Pollack, and Michael W. Otto. 2018. “Anxiety Sensitivity Moderates Drug Cravings in Response to Induced Negative Affect in Opioid Dependent Outpatients”. Addictive Behaviors. Elsevier BV. doi:10.1016/j.addbeh.2018.03.020.
Neurobehavioral HIV MedicineJournal
Rates of Mood and Anxiety Disorders and Contributors to Continued Heroin Use in Methadone Maintenance Patients: A Comparison by HIV Status
Applebaum. 2010. “Rates of Mood and Anxiety Disorders and Contributors to Continued Heroin Use in Methadone Maintenance Patients: A Comparison by HIV Status”. Neurobehavioral HIV Medicine. Informa UK Limited. doi:10.2147/nbhiv.s12371.
~18 spots leftby Apr 2025
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