Implementation Strategies for Medication-Assisted Treatment for Opioid Addiction
(SITT-MAT Trial)
What You Need to Know Before You Apply
What is the purpose of this trial?
The purpose of this study is to expand access to medications for opioid use disorder (MOUD) in specialty addiction programs in Washington State. Sixty-four addiction treatment programs will participate in an adaptive implementation strategy trial that uses a stagewise implementation-to-target (stepped "care" type) approach whereby organizations engage in increasingly intensive implementation strategies as needed. Organizations are moved to a follow-up/sustainment arm once they have met the implementation targets described below. The design also includes an external comparator arm, which consists of 510 addiction treatment programs that are not participating in the study and will mimic as study controls.The sequence of implementation strategies are:1. Enhanced Monitoring and Feedback2. NIATx/MAT Academy3. Randomization to either NIATx Internal Facilitation or NIATx External Facilitation4. Assignment to NIATx External Facilitation if outcome targets are not achieved in the NIATx Internal Facilitation armImplementation targets are:1. Reach - At least 75% of patients with opioid use disorder (OUD) receiving MOUD for three consecutive months2. Adoption - At least 1 integrated MOUD prescriber actively prescribing MOUD3. Implementation - a total score ≥ 4 on the Integrating Medications for Addiction Treatment (IMAT) Index.Contextual moderators and mediators of performance on target outcomes as a function of the implementation strategy step will be examined, as will the costs associated with participation in the sequence of implementation strategies.
Will I have to stop taking my current medications?
The trial information does not specify whether participants must stop taking their current medications. It focuses on expanding access to medications for opioid use disorder in treatment programs.
Is medication-assisted treatment for opioid addiction safe for humans?
The safety of medication-assisted treatment (MAT) for opioid addiction has been evaluated in various studies. For example, a study on naltrexone, a medication used in MAT, showed that it was generally well-tolerated by patients with heroin addiction. Additionally, a digital therapeutic adjunct to buprenorphine, another MAT medication, was evaluated for safety in a clinical trial, indicating that these treatments are generally safe for human use.12345
How does the Enhanced Monitoring and Feedback (EMF) treatment for opioid addiction differ from other treatments?
What data supports the effectiveness of this treatment for opioid addiction?
The NIATx approach, which is part of the treatment strategies being studied, has been shown to improve access to and retention in addiction treatment programs by reducing the time to start treatment and increasing the number of patients who continue with their care. This suggests that similar strategies could be effective in supporting medication-assisted treatment for opioid addiction.46101112
Who Is on the Research Team?
Mark McGovern, PhD
Principal Investigator
Stanford University
James H Ford II, PhD
Principal Investigator
University of Wisconsin, Madison
Are You a Good Fit for This Trial?
This trial is for addiction treatment programs in Washington State that handle opioid use disorder but are not opioid treatment programs. It includes residential detox or rehab, outpatient services, primary care clinics like FQHCs and CHCs.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Enhanced Monitoring and Feedback
Organizations engage in enhanced monitoring and feedback to improve MOUD implementation
NIATx/MAT Academy
Organizations participate in NIATx/MAT Academy to enhance MOUD implementation strategies
Facilitation
Randomization to either NIATx Internal Facilitation or NIATx External Facilitation, with potential reassignment to External Facilitation if targets are not met
Follow-up/Sustainment
Organizations are moved to a follow-up/sustainment arm once they have met the implementation targets
What Are the Treatments Tested in This Trial?
Interventions
- Enhanced Monitoring and Feedback (EMF)
- NIATx-External Facilitation (NIATx-EF)
- NIATx-Internal Facilitation (NIATx-IF)
- NIATx/MAT Academy
Find a Clinic Near You
Who Is Running the Clinical Trial?
Stanford University
Lead Sponsor
University of Wisconsin, Madison
Collaborator
Washington State Health Care Authority
Collaborator
National Institute on Drug Abuse (NIDA)
Collaborator