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Pre-hospital naloxone education for Musculoskeletal Pain

N/A
Waitlist Available
Led By Cassandra Mierisch, MD
Research Sponsored by Carilion Clinic
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 7 months (time from enrollment to 6 month follow-up phone call)
Awards & highlights

Summary

This trial tests if adding a short naloxone education session to pre-surgery classes helps patients and their support persons be ready to use naloxone in case of an opioid overdose. It targets patients having hip or knee surgery who will use opioids for pain. Naloxone can save lives by reversing opioid overdoses. Naloxone is a medication that can reverse opioid overdoses and has been used in various community and clinical settings to reduce mortality.

Eligible Conditions
  • Opioid Overdose
  • Musculoskeletal Pain
  • Opioid Use Disorder
  • Surgery

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~7 months (time from enrollment to 6 month follow-up phone call)
This trial's timeline: 3 weeks for screening, Varies for treatment, and 7 months (time from enrollment to 6 month follow-up phone call) for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Naloxone
Secondary outcome measures
Amount of opioid used at home
Naloxone
Correlation between patient comorbidities (described by International Classification of Diseases 9/10 code and "Readiness to Use Naloxone"
+14 more

Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: Naloxone educationExperimental Treatment1 Intervention
These participants will receive a pre-hospital naloxone education module during their pre-operative joint class
Group II: Standard EducationActive Control1 Intervention
These participants will receive the standard pre-hospital education including pain management and opioid safety, but will not specifically be given the new naloxone-education module in the pre-hospital setting

Find a Location

Who is running the clinical trial?

Carilion ClinicLead Sponsor
74 Previous Clinical Trials
12,562 Total Patients Enrolled
Virginia Polytechnic Institute and State UniversityOTHER
146 Previous Clinical Trials
27,953 Total Patients Enrolled
Cassandra Mierisch, MDPrincipal InvestigatorCarilion Clinic
2 Previous Clinical Trials
421 Total Patients Enrolled
~125 spots leftby Sep 2025
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