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Non-Invasive Ventilation for Pulmonary Atelectasis

N/A

Waitlist Available

Led By Robert Kacmarek, RRT, PhD

Research Sponsored by Massachusetts General Hospital

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up changes from baseline [0 peep] at titrated peep level (30 minutes after baseline)

Awards & highlights

Study Summary

This trial will help researchers learn more about how obesity impacts respiratory and cardiovascular function, by studying two different groups of obese volunteers.

Eligible Conditions

Pulmonary Atelectasis
Magnetic Resonance Imaging (MRI)
Obesity
Electrical Impedance Tomography
Obesity Hypoventilation Syndrome
Echocardiogram
Respiratory Mechanics

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ change from baseline [0 peep] to titrated peep level (30 minutes after baseline)

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~change from baseline [0 peep] to titrated peep level (30 minutes after baseline)

This trial's timeline: 3 weeks for screening, Varies for treatment, and change from baseline [0 peep] to titrated peep level (30 minutes after baseline) for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

End Expiratory Lung Volume

Secondary outcome measures

Heart ejection fraction

Right heart volumes

Work of breathing

Trial Design

1Treatment groups

Experimental Treatment

Group I: TreatmentExperimental Treatment2 Interventions

Volunteers with a BMI > 35 Kg/m2 and central fat distribution, without any past medical history

Treatment

First Studied

Drug Approval Stage

How many patients have taken this drug

Non-Invasive Ventilation

2007

N/A

~480

Do I qualify?Apply below to find out

Find a Location

Who is running the clinical trial?

Massachusetts General HospitalLead Sponsor

2,933 Previous Clinical Trials

13,198,446 Total Patients Enrolled

2 Trials studying Pulmonary Atelectasis

81 Patients Enrolled for Pulmonary Atelectasis

Robert Kacmarek, RRT, PhDPrincipal InvestigatorMassachussets General Hospital

3 Previous Clinical Trials

110 Total Patients Enrolled

1 Trials studying Pulmonary Atelectasis

21 Patients Enrolled for Pulmonary Atelectasis

Lorenzo Berra, MDPrincipal InvestigatorMassachusetts General Hospital

16 Previous Clinical Trials

799 Total Patients Enrolled

1 Trials studying Pulmonary Atelectasis

21 Patients Enrolled for Pulmonary Atelectasis

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Does the age restriction for this experiment extend beyond 65 years old?

"This trial is only open to applicants aged between 18 and 65. For those under the age of 18 or over 65, there are 213 clinical trials available for the former group and 645 for latter."

Answered by AI

Who can be enrolled in this clinical experiment?

"This clinical study is seeking out 35 obese participants, aged between 18 and 65 years old. Aside from that, selected patients must provide a form of photo identification, have a BMI above 35 kg/m2 for women or 102 cm for men, and also possess an abdominal circumference over 88 cm (for female candidates)."

Answered by AI

Are enrollees still being accepted into this clinical research?

"The clinical trial hosted on clinicaltrials.gov does not appear to be recruiting patients currently, as it was last updated on November 16th 2020. Nonetheless, there are over 1,500 other studies that require participants and are actively searching for volunteers now."

Answered by AI

Recent research and studies

Journal of Applied PhysiologyJournal

Respiratory Restriction and Elevated Pleural and Esophageal Pressures in Morbid Obesity

Behazin, Negin, Stephanie B. Jones, Robert I. Cohen, and Stephen H. Loring. 2010. “Respiratory Restriction and Elevated Pleural and Esophageal Pressures in Morbid Obesity”. Journal of Applied Physiology. American Physiological Society. doi:10.1152/japplphysiol.91356.2008.

AnesthesiologyJournal

Prevention of Atelectasis in Morbidly Obese Patients During General Anesthesia and Paralysis

Reinius, Henrik, Lennart Jonsson, Sven Gustafsson, Magnus Sundbom, Olov Duvernoy, Paolo Pelosi, Göran Hedenstierna, and Filip Fredén. 2009. “Prevention of Atelectasis in Morbidly Obese Patients During General Anesthesia and Paralysis”. Anesthesiology. Ovid Technologies (Wolters Kluwer Health). doi:10.1097/aln.0b013e3181b87edb.

ThoraxJournal

Observational Study of the Effect of Obesity on Lung Volumes

Steier, Joerg, Alan Lunt, Nicholas Hart, Michael I Polkey, and John Moxham. 2014. “Observational Study of the Effect of Obesity on Lung Volumes”. Thorax. BMJ. doi:10.1136/thoraxjnl-2014-205148.

Journal of Applied PhysiologyJournal