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Exercise for Obesity

N/A

Recruiting

Research Sponsored by University of Virginia

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Females must be premenopausal and report normal menstrual cycles

18-55 years of age

Timeline

Screening 3 weeks

Treatment Varies

Follow Up insulin and glucose will be collected at 5 timepoints during the ogtt, and 11 timepoints during each testing visit. the matsuda index (mathematical model) will be used to calculate insulin sensitivity

Awards & highlights

Study Summary

This trial is testing the impact of exercise intensity on the hormone ghrelin, as well as how changes in ghrelin from exercise affect obesity, insulin sensitivity, and vascular function.

Who is the study for?

This trial is for untrained individuals aged 18-55 with a BMI of 18-40 who haven't had significant weight changes recently. Premenopausal women with normal menstrual cycles can join, but not those pregnant, on fertility treatments, or with disordered eating. Smokers and those on certain medications or with diabetes, gastrointestinal, or endocrine disorders cannot participate.Check my eligibility

What is being tested?

The study explores how different exercise intensities affect ghrelin hormone levels and their impact on insulin sensitivity, obesity, and vascular health. Participants will engage in varying exercise routines to determine these relationships.See study design

What are the potential side effects?

While the study focuses on exercise which typically has benefits like improved fitness and mood, potential side effects may include muscle soreness, fatigue, joint pain or injury due to physical activity.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

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I am a premenopausal woman with regular menstrual cycles.

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I am between 18 and 55 years old.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ measured at 5 timepoints over 2-3 hours during each experimental visit

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~measured at 5 timepoints over 2-3 hours during each experimental visit

This trial's timeline: 3 weeks for screening, Varies for treatment, and measured at 5 timepoints over 2-3 hours during each experimental visit for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Ghrelin

Secondary outcome measures

Appetite Questionnaire (VAS)

Vascular Function (brachial flow mediated dilation)

Other outcome measures

Body Composition

Insulin Sensitivity

Trial Design

3Treatment groups

Experimental Treatment

Active Control

Group I: Moderate Intensity ExerciseExperimental Treatment1 Intervention

This group will exercise on a cycle ergometer (Lode Bike) at moderate intensity. Moderate intensity will be defined by the lactate threshold. A heart rate monitor will be utilized at all times to record heart rate.

Group II: High Intensity ExerciseExperimental Treatment1 Intervention

This group will exercise on a cycle ergometer (Lode Bike) at high intensity. High intensity will be defined by an by 75% of the difference between the lactate threshold and peak.

Group III: ControlActive Control1 Intervention

This arm will receive no exercise

0 / 2Eligibility criteria met

Find a Location

Who is running the clinical trial?

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)NIH

2,359 Previous Clinical Trials

4,314,512 Total Patients Enrolled

446 Trials studying Obesity

588,858 Patients Enrolled for Obesity

University of VirginiaLead Sponsor

754 Previous Clinical Trials

1,244,993 Total Patients Enrolled

17 Trials studying Obesity

2,452 Patients Enrolled for Obesity

Media Library

Exercise Clinical Trial Eligibility Overview. Trial Name: NCT04581980 — N/A

Obesity Research Study Groups: Moderate Intensity Exercise, High Intensity Exercise, Control

Obesity Clinical Trial 2023: Exercise Highlights & Side Effects. Trial Name: NCT04581980 — N/A

Exercise 2023 Treatment Timeline for Medical Study. Trial Name: NCT04581980 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is enrollment in this medical trial open to individuals aged twenty-five or older?

"This medical study seeks patients aged 40 to 55 for its clinical trial. Additionally, there are 220 trials that admit applicants below 18 years of age and 725 studies open to people 65 or older."

Answered by AI

Is enrollment for this trial still open?

"As shown on the clinicaltrials.gov website, this trial is still actively recruiting participants who are willing to take part in it. This research project was initially posted on October 14th 2020 and underwent its most recent update on May 13th 2022."

Answered by AI

Do I fulfill the qualifications for participation in this clinical experimentation?

"This medical trial has a target of 80 participants who must be between 40 and 55 years old, with insulin resistance as the primary qualification."

Answered by AI

How many people have signed up to partake in this research?

"Affirmative. The information on clinicaltrials.gov affirms that this research is currently accepting participants. This study was unveiled on October 14th 2020 and the latest update was made on May 13th 2022, with a requirement of 80 patients across 1 medical facility."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Effects of Obesity and Intensity of Exercise on Ghrelin Levels

Arthur L Weltman 2020. "Effects of Obesity and Intensity of Exercise on Ghrelin Levels". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT04581980.

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