Exercise for Normal-weight Obesity

(AHA-NWO Trial)

Overseen By Bree Baker, PhD

Age: 18+

Sex: Male

Trial Phase: Academic

Sponsor: Oklahoma State University

Disqualifiers: Chronic health condition, Excessive alcohol, others

No Placebo Group All trial participants will receive the active study treatment (no placebo)

Compensation: Varies

Number of Visits: Unknown

Duration: 12 weeks

96 Participants Needed

Trial Summary

What is the purpose of this trial?

The overall objective of this project is to advance understanding of the causes of normal weight obesity (NWO) in men, namely the hormone profile and related potential mediating mechanisms, and the efficacy of different modes of exercise to restore body composition and cardiometabolic health in this population.

Research Team

Sam Emerson, PhD

Principal Investigator

Oklahoma State University

Eligibility Criteria

This trial is for biological males who are willing to exercise, have a BMI between 18.5 - 24.9 or above 30, and body fat below 20% or above 25%. It's not for those with excessive alcohol, tobacco, vape use, illicit drugs, electrical implants like pacemakers, chronic health conditions or on medications impacting the study.

Inclusion Criteria

Ability and willingness to engage in an exercise training regimen

BMI 18.5 - 24.9 kg/m2 or >/= 30 kg/m2

Body fat <20% or >/= 25%

Exclusion Criteria

Excessive alcohol use or use of tobacco products, vape products, or illicit drugs

Presence of an electrical implant, such as a pacemaker

I have a chronic condition or take regular medication that could affect the study.

Timeline

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Treatment

Participants undergo 12 weeks of progressive and individualized exercise training, either aerobic or resistance

12 weeks

Follow-up

Participants are monitored for safety and effectiveness after treatment

4 weeks

Treatment Details

Interventions

• Aerobic Exercise Training
• Resistance Exercise Training

Trial Overview The study aims to understand how body composition and sex hormones interact in men with normal weight obesity (NWO) and assesses the effectiveness of resistance versus aerobic exercise training in improving their body composition and cardiometabolic health.

Participant Groups

Group I: Resistance Exercise Training Experimental Treatment 2 Interventions

12-weeks of progressive and individualized resistance exercise training

Group II: Aerobic Exercise Training Active Control 2 Interventions

12-weeks of progressive and individualized aerobic exercise training

Who Is Running the Clinical Trial?

Oklahoma State University

Lead Sponsor

Trials

51

Recruited

8,600+

American Heart Association

Collaborator

Trials

352

Recruited

6,196,000+