Mechanical vs Anatomical Alignment in Knee Replacement
Trial Summary
What is the purpose of this trial?
Current practice in orthopedics is to recommend TKA implantation with the femoral and tibial components perpendicular to their mechanical axis. Therefore, current surgical technique does not replicate natural knee anatomy and biomechanics. An alternative alignment method that attempts to replicate the kinematics of the knee is " kinematic alignment ". The principle behind kinematic alignment is placement of the TKA components so that the orthogonal 3-D orientation of the 3 axes that describe normal knee kinematics is restored to that of the prearthritic knee. Theoretical benefits of kinematic alignment include less ligamentous release to balance the knee intra-operatively, more rapid recovery, better range of motion (ROM), less post-operative pain, better knee biomechanics, and improved patient satisfaction. However, a major concern is that there are no mid- or long-term data on implant survivorship (absence of loosening) in TKA based on "anatomical" implantation. The investigators propose to compare the clinical results of TKA implanted with mechanical alignment (standard practice) to kinematic alignment, in a double-blind, randomized trial.
Research Team
Pascal Andre Vendittoli, MD, MSc
Principal Investigator
Research Director and surgeon
Eligibility Criteria
This trial is for adults who need a total knee replacement (TKA) and can give informed consent. It's not for those under 18, with infections in the leg, severe knee instability or deformity, hip replacements on the same side, substance abuse issues, mental disorders, pregnant women, allergies to implant materials, neuromuscular diseases affecting the limb or other lower limb joint damage.Inclusion Criteria
Exclusion Criteria
Treatment Details
Interventions
- Anatomical TKA
- Mechanical TKA
Find a Clinic Near You
Who Is Running the Clinical Trial?
Maisonneuve-Rosemont Hospital
Lead Sponsor