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NOL Index Response for Postoperative Pain Management

N/A
Recruiting
Research Sponsored by Ciusss de L'Est de l'Île de Montréal
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Adult patient (Age 18 or older)
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 3 months
Awards & highlights

Study Summary

This trial looks at whether a patient's response to a standardized pain stimulus during anesthesia is linked with post-operative pain levels and opioid consumption.

Who is the study for?
This trial is for adults over 18 who are scheduled for elective chest surgery (VATS) under general anesthesia, with a health status classified as ASA I, II or III. It's not suitable for those allergic to study drugs, with substance abuse history, chronic use of psychotropic/opioid drugs, psychiatric diseases, heart issues like coronary artery disease or serious arrhythmias.Check my eligibility
What is being tested?
The study looks at how well the NoL index—a pain response indicator—predicts post-surgery pain and opioid need after chest surgery. Researchers will measure this response to a standardized stimulus during anesthesia and compare it to actual pain and opioid use after surgery.See study design
What are the potential side effects?
Since this trial focuses on measuring responses rather than testing new treatments, side effects may be limited to typical surgical and anesthesia risks such as discomfort from the stimulus used in the test or reactions related to standard medications administered.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
Select...
I am 18 years old or older.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~3 months
This trial's timeline: 3 weeks for screening, Varies for treatment, and 3 months for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Correlation between NoL index and Hydromorphone consumption H24
Secondary outcome measures
Biomarkers level H24
Tumor Markers
Biomarkers level Pre-op
+24 more

Trial Design

1Treatment groups
Experimental Treatment
Group I: Included patientsExperimental Treatment4 Interventions
There is only one arm in this study. Intervention will be electrical forearm stimulus under general anesthesia and the response of NOL index following this stimulus and its correlation with postoperative parameters such as pain and opioid consumption in post anesthesia care unit.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Biomarkers
2018
N/A
~100

Find a Location

Who is running the clinical trial?

Ciusss de L'Est de l'Île de MontréalLead Sponsor
70 Previous Clinical Trials
5,491 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
clinicaltrials.govStudy
Correlation Between NOL Index After Stimulus and Post-operative Opioid, Pain, Pre-operative Phenotype
Philippe Richebe 2018. "Correlation Between NOL Index After Stimulus and Post-operative Opioid, Pain, Pre-operative Phenotype". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT03422783.
All > Opiate Addiction
~1 spots leftby Jun 2024
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