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Diagnostic Test

Whole Body MRI for Neurofibromatosis

N/A
Waitlist Available
Led By Miriam Bornhorst, MD
Research Sponsored by Children's National Research Institute
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be younger than 65 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 3-4 years
Awards & highlights

Study Summary

This study is evaluating whether whole body MRI can be used to identify atypical neurofibromas in neurofibromatosis type 1 patients with high tumor burden.

Eligible Conditions
  • Neurofibromatosis
  • Neurofibroma
  • Plexiform Neurofibroma

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~3-4 years
This trial's timeline: 3 weeks for screening, Varies for treatment, and 3-4 years for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
To determine if WBMRI can be used to identify ANF in NF1 patients with high tumor burden.
Secondary outcome measures
Determine if clinical signs and symptoms correlate with tumor burden and/or the presence of ANF on WBMRI
Other outcome measures
Determine if the cfDNA levels correlate with presence of ANF.

Trial Design

1Treatment groups
Experimental Treatment
Group I: Study ArmExperimental Treatment1 Intervention
Whole Body MRI along with standard of care regional MRI and blood draw at enrollment followed by Whole Body MRI along with standard of care regional MRI and blood draw after 4-6 months.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Whole Body MRI
2007
N/A
~40

Find a Location

Who is running the clinical trial?

Children's National Research InstituteLead Sponsor
209 Previous Clinical Trials
207,735 Total Patients Enrolled
Miriam Bornhorst, MDPrincipal InvestigatorChildren's National Health System
1 Previous Clinical Trials

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
clinicaltrials.govStudy
Whole Body MRI to Identify Atypical Neurofibromas in Patients With NF1
Miriam Bornhorst 2018. "Whole Body MRI to Identify Atypical Neurofibromas in Patients With NF1". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT03820778.
All > Nf 1
~1 spots leftby Apr 2025
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