Cognitive behavioral therapy for Anhedonia

Phase-Based Progress Estimates
1
Effectiveness
1
Safety
Fralin Biomedical Research Institute at Virginia Tech Carilion, Roanoke, VA
Anhedonia+1 More
cognitive behavioral therapy - Behavioral
Eligibility
18 - 65
All Sexes
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Study Summary

This trial looks at how different people react to winning or losing, and if these responses are different for people who have depression, anhedonia, or anxiety. Cognitive behavioral therapy is being used to treat Anhedonia in this trial, and no patients will receive a placebo.

Eligible Conditions

  • Anhedonia
  • Neurobehavioral Components of Reward and Loss Valuation

Treatment Effectiveness

Study Objectives

1 Primary · 3 Secondary · Reporting Duration: study entrance to exit, an average of 12 weeks

Week 12
change in anhedonia symptoms (anhedonia subscale; Mood and Anxiety Symptom Questionnaire)
change in anxiety symptoms (anxiety subscale; Mood and Anxiety Symptom Questionnaire)
change in depression symptoms (Beck Depression Inventory)
Week 12
change in proportion correct on the 'N-arm bandit learning task'

Trial Safety

Trial Design

3 Treatment Groups

Cognitive behavioral therapy
1 of 3
Valuation without instruction
1 of 3
Valuation with instruction
1 of 3
Active Control

252 Total Participants · 3 Treatment Groups

Primary Treatment: Cognitive behavioral therapy · No Placebo Group · N/A

Cognitive behavioral therapy
Behavioral
ActiveComparator Group · 1 Intervention: cognitive behavioral therapy · Intervention Types: Behavioral
Valuation without instruction
Behavioral
ActiveComparator Group · 1 Intervention: valuation without instruction · Intervention Types: Behavioral
Valuation with instruction
Behavioral
ActiveComparator Group · 1 Intervention: valuation with instruction · Intervention Types: Behavioral

Trial Logistics

Trial Timeline

Approximate Timeline
Screening: ~3 weeks
Treatment: Varies
Reporting: study entrance to exit, an average of 12 weeks
Closest Location: Fralin Biomedical Research Institute at Virginia Tech Carilion · Roanoke, VA
Photo of virginia 1Photo of virginia 2Photo of virginia 3
N/AFirst Recorded Clinical Trial
1 TrialsResearching Anhedonia
0 CompletedClinical Trials

Who is running the clinical trial?

Virginia Polytechnic Institute and State UniversityLead Sponsor
108 Previous Clinical Trials
25,282 Total Patients Enrolled

Eligibility Criteria

Age 18 - 65 · All Participants · 1 Total Inclusion Criteria

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About The Reviewer

Michael Gill preview

Michael Gill - B. Sc.

First Published: October 9th, 2021

Last Reviewed: August 12th, 2022

Michael Gill holds a Bachelors of Science in Integrated Science and Mathematics from McMaster University. During his degree he devoted considerable time modeling the pharmacodynamics of promising drug candidates. Since then, he has leveraged this knowledge of the investigational new drug ecosystem to help his father navigate clinical trials for multiple myeloma, an experience which prompted him to co-found Power Life Sciences: a company that helps patients access randomized controlled trials.