← Back to Search

Proton Beam Therapy

Proton Therapy for Brain Cancer

N/A

Waitlist Available

Led By Bree R Eaton

Research Sponsored by Emory University

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Pathologic diagnosis of central nervous system malignancy requiring craniospinal irradiation

Be younger than 65 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up up to 2 years

Awards & highlights

Study Summary

This trial is testing a new way to give radiation therapy for cancer that starts in the spine. The new way may cause less damage to the bones in the spine.

Who is the study for?

This trial is for pediatric patients with a confirmed diagnosis of cancer in the central nervous system who need craniospinal irradiation. Participants must be able to undergo MRI scans and not have any major illnesses that could affect study participation. Pregnant or potentially pregnant females are excluded.Check my eligibility

What is being tested?

The trial is testing intensity-modulated proton therapy, an advanced type of radiation treatment aimed at killing cancer cells while sparing the bones of the vertebral column from radiation exposure, potentially reducing side effects.See study design

What are the potential side effects?

Potential side effects may include skin reactions, fatigue, hair loss at treated sites, nausea, and other symptoms related to reduced radiation exposure to healthy spinal tissue.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Select...

I have a brain or spinal cord tumor that needs radiation treatment.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ up to 2 years

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~up to 2 years

This trial's timeline: 3 weeks for screening, Varies for treatment, and up to 2 years for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Bone Marrow

Dose delivered to vertebral bodies and quality assurance of treatment plans

Incidence and severity of acute hematologic toxicity

Trial Design

1Treatment groups

Experimental Treatment

Group I: Treatment (intensity modulated proton therapy)Experimental Treatment2 Interventions

Patients undergo intensity modulated proton therapy once daily over 30 fractions and also undergo MRI over 20 minutes during fractions 7, 13, 20, and 30 of radiation in the absence of disease progression or unacceptable toxicity.

Treatment

First Studied

Drug Approval Stage

How many patients have taken this drug

Intensity-Modulated Proton Therapy

2019

N/A

~10

Magnetic Resonance Imaging

2017

Completed Phase 3

~1190

0 / 1Eligibility criteria met

Find a Location

Who is running the clinical trial?

Emory UniversityLead Sponsor

1,638 Previous Clinical Trials

2,560,522 Total Patients Enrolled

National Institutes of Health (NIH)NIH

2,696 Previous Clinical Trials

6,952,529 Total Patients Enrolled

National Cancer Institute (NCI)NIH

13,658 Previous Clinical Trials

40,924,479 Total Patients Enrolled

Media Library

Intensity-Modulated Proton Therapy (Proton Beam Therapy) Clinical Trial Eligibility Overview. Trial Name: NCT04276194 — N/A

Brain Cancer Research Study Groups: Treatment (intensity modulated proton therapy)

Brain Cancer Clinical Trial 2023: Intensity-Modulated Proton Therapy Highlights & Side Effects. Trial Name: NCT04276194 — N/A

Intensity-Modulated Proton Therapy (Proton Beam Therapy) 2023 Treatment Timeline for Medical Study. Trial Name: NCT04276194 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Am I able to participate in this exploration?

"For this research project, a cohort of 10 children between the ages 3 and 18 with central nervous system neoplasms is sought. Additionally, they must have received radiotherapy treatment for their malignancy, as well as given written consent in order to be considered eligible participants."

Answered by AI

Are persons of a younger age group eligible to participate in this trial?

"According to the criteria for participation, minors aged 3 to 18 are qualified applicants. Of those eligible under 18 years old, 77 people can join this trial; conversely, older adults over 65 have 50 opportunities."

Answered by AI

Is this research study currently enrolling participants?

"Clinicaltrials.gov data points to the conclusion that this medical trial is not actively recruiting patients anymore; the study was initially posted on December 16th 2019 and last modified on February 28th 2022. Fortunately, 116 other clinical trials are currently open for patient recruitment at present."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Vertebral Body Sparing Craniospinal Irradiation for Pediatric Patients With Cancer of the Central Nervous System

Bree Eaton 2019. "Vertebral Body Sparing Craniospinal Irradiation for Pediatric Patients With Cancer of the Central Nervous System". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT04276194.